HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.

HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.

Classically, HLA-DR expressed on antigen presenting cells (APC) initiates lymphocyte activation via presentation of peptides to TCR bearing CD4+ T-Cells. Here we demonstrate that HLA-DR alpha 2 domain (sHLA-DRalpha2) also induces negative signals by engaging TIRC7 on lymphocytes. This interaction in...

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Main Authors: Grit-Carsta Bulwin, Stephanie Wälter, Mirko Schlawinsky, Thomas Heinemann, Anke Schulze, Wolfgang Höhne, Gerd Krause, Wiltrud Kalka-Moll, Patricia Fraser, Hans-Dieter Volk, Jürgen Löhler, Edgar L Milford, Nalân Utku
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f93ba63cc3d54d8b9ebdecf43a081894
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https://doaj.org/article/f93ba63cc3d54d8b9ebdecf43a081894

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