Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP

Abstract The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contra...

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Autores principales:	Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Ursula Hoffmann, Christian Fastner, Martin Borggrefe, Thomas Roth, Jakob Triebel, Thomas Bertsch, Ibrahim Akin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f93d4c3850314cd5b02bdb5a1b6e45aa
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spelling	oai:doaj.org-article:f93d4c3850314cd5b02bdb5a1b6e45aa2021-12-02T16:06:00ZPercutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP10.1038/s41598-017-08999-42045-2322https://doaj.org/article/f93d4c3850314cd5b02bdb5a1b6e45aa2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08999-4https://doaj.org/toc/2045-2322Abstract The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindication for oral anticoagulant therapy were enrolled. Blood samples were taken within 24 hours before (T1) and at least 6 months (mid-term) (T2) after successful implantation of LAA occlusion devices. Blood levels of high sensitivity troponin I and T (hsTnI, hsTnT), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) were evaluated at both time points. A total of 42 patients with successful percutaneous LAA closure were included. Median mid-term follow-up was of 183 days. HsTnT, hsTnI and NT-proBNP did not show any significant differences over time. Serum levels of MR-proANP increased significantly between immediate pre-intervention (T1: median = 245.7 pmol/l, IQR 155.8–361.3 pmol/l) and at mid-term follow-up (T2: median = 254 pmol/l, IQR 183.4–396.4 pmol/l) (p = 0.037). These results indicate, that percutaneous LAA closure affects neuro-humoral haemostasis by increasing MR-proANP serum levels at mid-term follow-up.Michael BehnesBenjamin SartoriusAnnika WenkeSiegfried LangUrsula HoffmannChristian FastnerMartin BorggrefeThomas RothJakob TriebelThomas BertschIbrahim AkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Behnes Benjamin Sartorius Annika Wenke Siegfried Lang Ursula Hoffmann Christian Fastner Martin Borggrefe Thomas Roth Jakob Triebel Thomas Bertsch Ibrahim Akin Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
description	Abstract The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindication for oral anticoagulant therapy were enrolled. Blood samples were taken within 24 hours before (T1) and at least 6 months (mid-term) (T2) after successful implantation of LAA occlusion devices. Blood levels of high sensitivity troponin I and T (hsTnI, hsTnT), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) were evaluated at both time points. A total of 42 patients with successful percutaneous LAA closure were included. Median mid-term follow-up was of 183 days. HsTnT, hsTnI and NT-proBNP did not show any significant differences over time. Serum levels of MR-proANP increased significantly between immediate pre-intervention (T1: median = 245.7 pmol/l, IQR 155.8–361.3 pmol/l) and at mid-term follow-up (T2: median = 254 pmol/l, IQR 183.4–396.4 pmol/l) (p = 0.037). These results indicate, that percutaneous LAA closure affects neuro-humoral haemostasis by increasing MR-proANP serum levels at mid-term follow-up.
format	article
author	Michael Behnes Benjamin Sartorius Annika Wenke Siegfried Lang Ursula Hoffmann Christian Fastner Martin Borggrefe Thomas Roth Jakob Triebel Thomas Bertsch Ibrahim Akin
author_facet	Michael Behnes Benjamin Sartorius Annika Wenke Siegfried Lang Ursula Hoffmann Christian Fastner Martin Borggrefe Thomas Roth Jakob Triebel Thomas Bertsch Ibrahim Akin
author_sort	Michael Behnes
title	Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
title_short	Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
title_full	Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
title_fullStr	Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
title_full_unstemmed	Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP
title_sort	percutaneous closure of left atrial appendage affects mid-term release of mr-proanp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f93d4c3850314cd5b02bdb5a1b6e45aa
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Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP

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