The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes TFH differentiation and that low leptin levels can impair TFH response to vaccines and virus protec...

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Autores principales: Jun Deng, Qian Chen, Zhian Chen, Kaili Liang, Xin Gao, Xiaohui Wang, Fadzai V. Makota, Hong Sheng Ong, Yanmin Wan, Kaiming Luo, Dongcheng Gong, Xiang Yu, Sarina Camuglia, Qunxiong Zeng, Tao Zhou, Feng Xue, Jing He, Yunbo Wei, Fan Xiao, Jianyang Ma, Danika L. Hill, Wim Pierson, Thi H. O. Nguyen, Haibo Zhou, Yan Wang, Wei Shen, Lingyun Sun, Zhanguo Li, Qiang Xia, Kun Qian, Lilin Ye, Steven Rockman, Michelle A. Linterman, Katherine Kedzierska, Nan Shen, Liwei Lu, Di Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/f941734e60144e5c8a46d9bfedb1e122
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spelling oai:doaj.org-article:f941734e60144e5c8a46d9bfedb1e1222021-12-02T15:49:48ZThe metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses10.1038/s41467-021-23220-x2041-1723https://doaj.org/article/f941734e60144e5c8a46d9bfedb1e1222021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23220-xhttps://doaj.org/toc/2041-1723T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes TFH differentiation and that low leptin levels can impair TFH response to vaccines and virus protection in mice.Jun DengQian ChenZhian ChenKaili LiangXin GaoXiaohui WangFadzai V. MakotaHong Sheng OngYanmin WanKaiming LuoDongcheng GongXiang YuSarina CamugliaQunxiong ZengTao ZhouFeng XueJing HeYunbo WeiFan XiaoJianyang MaDanika L. HillWim PiersonThi H. O. NguyenHaibo ZhouYan WangWei ShenLingyun SunZhanguo LiQiang XiaKun QianLilin YeSteven RockmanMichelle A. LintermanKatherine KedzierskaNan ShenLiwei LuDi YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Deng
Qian Chen
Zhian Chen
Kaili Liang
Xin Gao
Xiaohui Wang
Fadzai V. Makota
Hong Sheng Ong
Yanmin Wan
Kaiming Luo
Dongcheng Gong
Xiang Yu
Sarina Camuglia
Qunxiong Zeng
Tao Zhou
Feng Xue
Jing He
Yunbo Wei
Fan Xiao
Jianyang Ma
Danika L. Hill
Wim Pierson
Thi H. O. Nguyen
Haibo Zhou
Yan Wang
Wei Shen
Lingyun Sun
Zhanguo Li
Qiang Xia
Kun Qian
Lilin Ye
Steven Rockman
Michelle A. Linterman
Katherine Kedzierska
Nan Shen
Liwei Lu
Di Yu
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
description T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes TFH differentiation and that low leptin levels can impair TFH response to vaccines and virus protection in mice.
format article
author Jun Deng
Qian Chen
Zhian Chen
Kaili Liang
Xin Gao
Xiaohui Wang
Fadzai V. Makota
Hong Sheng Ong
Yanmin Wan
Kaiming Luo
Dongcheng Gong
Xiang Yu
Sarina Camuglia
Qunxiong Zeng
Tao Zhou
Feng Xue
Jing He
Yunbo Wei
Fan Xiao
Jianyang Ma
Danika L. Hill
Wim Pierson
Thi H. O. Nguyen
Haibo Zhou
Yan Wang
Wei Shen
Lingyun Sun
Zhanguo Li
Qiang Xia
Kun Qian
Lilin Ye
Steven Rockman
Michelle A. Linterman
Katherine Kedzierska
Nan Shen
Liwei Lu
Di Yu
author_facet Jun Deng
Qian Chen
Zhian Chen
Kaili Liang
Xin Gao
Xiaohui Wang
Fadzai V. Makota
Hong Sheng Ong
Yanmin Wan
Kaiming Luo
Dongcheng Gong
Xiang Yu
Sarina Camuglia
Qunxiong Zeng
Tao Zhou
Feng Xue
Jing He
Yunbo Wei
Fan Xiao
Jianyang Ma
Danika L. Hill
Wim Pierson
Thi H. O. Nguyen
Haibo Zhou
Yan Wang
Wei Shen
Lingyun Sun
Zhanguo Li
Qiang Xia
Kun Qian
Lilin Ye
Steven Rockman
Michelle A. Linterman
Katherine Kedzierska
Nan Shen
Liwei Lu
Di Yu
author_sort Jun Deng
title The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
title_short The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
title_full The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
title_fullStr The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
title_full_unstemmed The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
title_sort metabolic hormone leptin promotes the function of tfh cells and supports vaccine responses
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f941734e60144e5c8a46d9bfedb1e122
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