GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.

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Detalles Bibliográficos
Autores principales: Yumeng Peng, Qiang Zeng, Luming Wan, Enhao Ma, Huilong Li, Xiaopan Yang, Yanhong Zhang, Linfei Huang, Haotian Lin, Jiangyue Feng, Yixin Xu, Jingfei Li, Muyi Liu, Jing Liu, Changqin Lin, Zhiwei Sun, Gong Cheng, Xuemiao Zhang, Jialong Liu, Dongrui Li, Meng Wei, Yunhai Mo, Xuetao Mu, Xiaowei Deng, Dandan Zhang, Siqing Dong, Hanqing Huang, Yi Fang, Qi Gao, Xiaoli Yang, Feixiang Wu, Hui Zhong, Congwen Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/f943bc14bfee407d92b112542d6d6eee
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Sumario:Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.

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