GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.

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Autores principales:	Yumeng Peng, Qiang Zeng, Luming Wan, Enhao Ma, Huilong Li, Xiaopan Yang, Yanhong Zhang, Linfei Huang, Haotian Lin, Jiangyue Feng, Yixin Xu, Jingfei Li, Muyi Liu, Jing Liu, Changqin Lin, Zhiwei Sun, Gong Cheng, Xuemiao Zhang, Jialong Liu, Dongrui Li, Meng Wei, Yunhai Mo, Xuetao Mu, Xiaowei Deng, Dandan Zhang, Siqing Dong, Hanqing Huang, Yi Fang, Qi Gao, Xiaoli Yang, Feixiang Wu, Hui Zhong, Congwen Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f943bc14bfee407d92b112542d6d6eee
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spelling	oai:doaj.org-article:f943bc14bfee407d92b112542d6d6eee2021-12-05T12:21:46ZGP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity10.1038/s41467-021-27309-12041-1723https://doaj.org/article/f943bc14bfee407d92b112542d6d6eee2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27309-1https://doaj.org/toc/2041-1723Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.Yumeng PengQiang ZengLuming WanEnhao MaHuilong LiXiaopan YangYanhong ZhangLinfei HuangHaotian LinJiangyue FengYixin XuJingfei LiMuyi LiuJing LiuChangqin LinZhiwei SunGong ChengXuemiao ZhangJialong LiuDongrui LiMeng WeiYunhai MoXuetao MuXiaowei DengDandan ZhangSiqing DongHanqing HuangYi FangQi GaoXiaoli YangFeixiang WuHui ZhongCongwen WeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yumeng Peng Qiang Zeng Luming Wan Enhao Ma Huilong Li Xiaopan Yang Yanhong Zhang Linfei Huang Haotian Lin Jiangyue Feng Yixin Xu Jingfei Li Muyi Liu Jing Liu Changqin Lin Zhiwei Sun Gong Cheng Xuemiao Zhang Jialong Liu Dongrui Li Meng Wei Yunhai Mo Xuetao Mu Xiaowei Deng Dandan Zhang Siqing Dong Hanqing Huang Yi Fang Qi Gao Xiaoli Yang Feixiang Wu Hui Zhong Congwen Wei GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
description	Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.
format	article
author	Yumeng Peng Qiang Zeng Luming Wan Enhao Ma Huilong Li Xiaopan Yang Yanhong Zhang Linfei Huang Haotian Lin Jiangyue Feng Yixin Xu Jingfei Li Muyi Liu Jing Liu Changqin Lin Zhiwei Sun Gong Cheng Xuemiao Zhang Jialong Liu Dongrui Li Meng Wei Yunhai Mo Xuetao Mu Xiaowei Deng Dandan Zhang Siqing Dong Hanqing Huang Yi Fang Qi Gao Xiaoli Yang Feixiang Wu Hui Zhong Congwen Wei
author_facet	Yumeng Peng Qiang Zeng Luming Wan Enhao Ma Huilong Li Xiaopan Yang Yanhong Zhang Linfei Huang Haotian Lin Jiangyue Feng Yixin Xu Jingfei Li Muyi Liu Jing Liu Changqin Lin Zhiwei Sun Gong Cheng Xuemiao Zhang Jialong Liu Dongrui Li Meng Wei Yunhai Mo Xuetao Mu Xiaowei Deng Dandan Zhang Siqing Dong Hanqing Huang Yi Fang Qi Gao Xiaoli Yang Feixiang Wu Hui Zhong Congwen Wei
author_sort	Yumeng Peng
title	GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
title_short	GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
title_full	GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
title_fullStr	GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
title_full_unstemmed	GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
title_sort	gp73 is a tbc-domain rab gtpase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f943bc14bfee407d92b112542d6d6eee
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GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

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