The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy

Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is increasingly regarded to fuel tumor recurrence. The concept of cancer cell dormancy is often considered as an adaptive response of cancer cells to st...

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Autores principales:	Bashar A. Alhasan, Sergei A. Gordeev, Aleksandra R. Knyazeva, Kseniia V. Aleksandrova, Boris A. Margulis, Irina V. Guzhova, Irina I. Suvorova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	embryonic stem cells embryonic diapause pluripotent stem cells pluripotency cancer cell dormancy autophagy Chemical technology TP1-1185 Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/f946712dfebb4e36b23f247a4a3b282b
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spelling	oai:doaj.org-article:f946712dfebb4e36b23f247a4a3b282b2021-11-25T18:19:51ZThe mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy10.3390/membranes111108582077-0375https://doaj.org/article/f946712dfebb4e36b23f247a4a3b282b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/858https://doaj.org/toc/2077-0375Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is increasingly regarded to fuel tumor recurrence. The concept of cancer cell dormancy is often considered as an adaptive response of cancer cells to stress, and, therefore, is limited. It is possible that the cancer dormant state is not a privilege of cancer cells but the same reproductive survival strategy as diapause used by embryonic stem cells (ESCs). Recent advances reveal that high autophagy and mTOR pathway reduction are key mechanisms contributing to dormancy and diapause. ESCs, sharing their main features with cancer stem cells, have a delicate balance between the mTOR pathway and autophagy activity permissive for diapause induction. In this review, we discuss the functioning of the mTOR signaling and autophagy in ESCs in detail that allows us to deepen our understanding of the biology of cancer cell dormancy.Bashar A. AlhasanSergei A. GordeevAleksandra R. KnyazevaKseniia V. AleksandrovaBoris A. MargulisIrina V. GuzhovaIrina I. SuvorovaMDPI AGarticleembryonic stem cellsembryonic diapausepluripotent stem cellspluripotencycancer cell dormancyautophagyChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 858, p 858 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	embryonic stem cells embryonic diapause pluripotent stem cells pluripotency cancer cell dormancy autophagy Chemical technology TP1-1185 Chemical engineering TP155-156
spellingShingle	embryonic stem cells embryonic diapause pluripotent stem cells pluripotency cancer cell dormancy autophagy Chemical technology TP1-1185 Chemical engineering TP155-156 Bashar A. Alhasan Sergei A. Gordeev Aleksandra R. Knyazeva Kseniia V. Aleksandrova Boris A. Margulis Irina V. Guzhova Irina I. Suvorova The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
description	Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is increasingly regarded to fuel tumor recurrence. The concept of cancer cell dormancy is often considered as an adaptive response of cancer cells to stress, and, therefore, is limited. It is possible that the cancer dormant state is not a privilege of cancer cells but the same reproductive survival strategy as diapause used by embryonic stem cells (ESCs). Recent advances reveal that high autophagy and mTOR pathway reduction are key mechanisms contributing to dormancy and diapause. ESCs, sharing their main features with cancer stem cells, have a delicate balance between the mTOR pathway and autophagy activity permissive for diapause induction. In this review, we discuss the functioning of the mTOR signaling and autophagy in ESCs in detail that allows us to deepen our understanding of the biology of cancer cell dormancy.
format	article
author	Bashar A. Alhasan Sergei A. Gordeev Aleksandra R. Knyazeva Kseniia V. Aleksandrova Boris A. Margulis Irina V. Guzhova Irina I. Suvorova
author_facet	Bashar A. Alhasan Sergei A. Gordeev Aleksandra R. Knyazeva Kseniia V. Aleksandrova Boris A. Margulis Irina V. Guzhova Irina I. Suvorova
author_sort	Bashar A. Alhasan
title	The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
title_short	The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
title_full	The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
title_fullStr	The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
title_full_unstemmed	The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
title_sort	mtor pathway in pluripotent stem cells: lessons for understanding cancer cell dormancy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f946712dfebb4e36b23f247a4a3b282b
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The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy

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