A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

DDRGK1 is an ER membrane protein that is subject to Ufm1 modification, but its function in ER homeostasis is unknown. Here, the authors show that ufmylated DDRGK1 interacts with and stabilizes the ER-stress sensor protein IRE1a, in turn repressing ER stress and apoptosis.

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Autores principales: Jiang Liu, Ying Wang, Lizhi Song, Linghua Zeng, Weiwei Yi, Ting Liu, Huanzhen Chen, Miao Wang, Zhenyu Ju, Yu-Sheng Cong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f947839b8b534eb288d8307e574f55e8
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spelling oai:doaj.org-article:f947839b8b534eb288d8307e574f55e82021-12-02T14:42:28ZA critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability10.1038/ncomms141862041-1723https://doaj.org/article/f947839b8b534eb288d8307e574f55e82017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14186https://doaj.org/toc/2041-1723DDRGK1 is an ER membrane protein that is subject to Ufm1 modification, but its function in ER homeostasis is unknown. Here, the authors show that ufmylated DDRGK1 interacts with and stabilizes the ER-stress sensor protein IRE1a, in turn repressing ER stress and apoptosis.Jiang LiuYing WangLizhi SongLinghua ZengWeiwei YiTing LiuHuanzhen ChenMiao WangZhenyu JuYu-Sheng CongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiang Liu
Ying Wang
Lizhi Song
Linghua Zeng
Weiwei Yi
Ting Liu
Huanzhen Chen
Miao Wang
Zhenyu Ju
Yu-Sheng Cong
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
description DDRGK1 is an ER membrane protein that is subject to Ufm1 modification, but its function in ER homeostasis is unknown. Here, the authors show that ufmylated DDRGK1 interacts with and stabilizes the ER-stress sensor protein IRE1a, in turn repressing ER stress and apoptosis.
format article
author Jiang Liu
Ying Wang
Lizhi Song
Linghua Zeng
Weiwei Yi
Ting Liu
Huanzhen Chen
Miao Wang
Zhenyu Ju
Yu-Sheng Cong
author_facet Jiang Liu
Ying Wang
Lizhi Song
Linghua Zeng
Weiwei Yi
Ting Liu
Huanzhen Chen
Miao Wang
Zhenyu Ju
Yu-Sheng Cong
author_sort Jiang Liu
title A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
title_short A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
title_full A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
title_fullStr A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
title_full_unstemmed A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
title_sort critical role of ddrgk1 in endoplasmic reticulum homoeostasis via regulation of ire1α stability
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f947839b8b534eb288d8307e574f55e8
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