A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

DDRGK1 is an ER membrane protein that is subject to Ufm1 modification, but its function in ER homeostasis is unknown. Here, the authors show that ufmylated DDRGK1 interacts with and stabilizes the ER-stress sensor protein IRE1a, in turn repressing ER stress and apoptosis.

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Autores principales: Jiang Liu, Ying Wang, Lizhi Song, Linghua Zeng, Weiwei Yi, Ting Liu, Huanzhen Chen, Miao Wang, Zhenyu Ju, Yu-Sheng Cong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f947839b8b534eb288d8307e574f55e8
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