Candida albicans gains azole resistance by altering sphingolipid composition

The fungal pathogen Candida albicans is diploid, which hinders genome-wide studies. Here, Gao et al. present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains, and use it to identify genes and mechanisms underlying azole resistance.

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Autores principales:	Jiaxin Gao, Haitao Wang, Zeyao Li, Ada Hang-Heng Wong, Yi-Zheng Wang, Yahui Guo, Xin Lin, Guisheng Zeng, Haoping Liu, Yue Wang, Jianbin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9482aff0bce438592c86a1e3d00feb0
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spelling	oai:doaj.org-article:f9482aff0bce438592c86a1e3d00feb02021-12-02T16:56:40ZCandida albicans gains azole resistance by altering sphingolipid composition10.1038/s41467-018-06944-12041-1723https://doaj.org/article/f9482aff0bce438592c86a1e3d00feb02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06944-1https://doaj.org/toc/2041-1723The fungal pathogen Candida albicans is diploid, which hinders genome-wide studies. Here, Gao et al. present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains, and use it to identify genes and mechanisms underlying azole resistance.Jiaxin GaoHaitao WangZeyao LiAda Hang-Heng WongYi-Zheng WangYahui GuoXin LinGuisheng ZengHaoping LiuYue WangJianbin WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiaxin Gao Haitao Wang Zeyao Li Ada Hang-Heng Wong Yi-Zheng Wang Yahui Guo Xin Lin Guisheng Zeng Haoping Liu Yue Wang Jianbin Wang Candida albicans gains azole resistance by altering sphingolipid composition
description	The fungal pathogen Candida albicans is diploid, which hinders genome-wide studies. Here, Gao et al. present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains, and use it to identify genes and mechanisms underlying azole resistance.
format	article
author	Jiaxin Gao Haitao Wang Zeyao Li Ada Hang-Heng Wong Yi-Zheng Wang Yahui Guo Xin Lin Guisheng Zeng Haoping Liu Yue Wang Jianbin Wang
author_facet	Jiaxin Gao Haitao Wang Zeyao Li Ada Hang-Heng Wong Yi-Zheng Wang Yahui Guo Xin Lin Guisheng Zeng Haoping Liu Yue Wang Jianbin Wang
author_sort	Jiaxin Gao
title	Candida albicans gains azole resistance by altering sphingolipid composition
title_short	Candida albicans gains azole resistance by altering sphingolipid composition
title_full	Candida albicans gains azole resistance by altering sphingolipid composition
title_fullStr	Candida albicans gains azole resistance by altering sphingolipid composition
title_full_unstemmed	Candida albicans gains azole resistance by altering sphingolipid composition
title_sort	candida albicans gains azole resistance by altering sphingolipid composition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f9482aff0bce438592c86a1e3d00feb0
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Candida albicans gains azole resistance by altering sphingolipid composition

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