Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia

Abstract The precise neural underpinnings of face pareidolia in patients with Parkinson’s disease (PD) remain unclear. We aimed to clarify face recognition network abnormalities associated with face pareidolia in such patients. Eighty-three patients with PD and 40 healthy controls were recruited in...

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Autores principales:	Yuta Kajiyama, Noriaki Hattori, Tomohito Nakano, Gajanan S. Revankar, Hironori Otomune, Ryota Hashimoto, Etsuro Mori, Manabu Ikeda, Masahito Mihara, Hideki Mochizuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f948faea33cf44cc9a1057dd2190bcd3
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spelling	oai:doaj.org-article:f948faea33cf44cc9a1057dd2190bcd32021-12-02T18:07:52ZDecreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia10.1038/s41531-021-00237-z2373-8057https://doaj.org/article/f948faea33cf44cc9a1057dd2190bcd32021-10-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00237-zhttps://doaj.org/toc/2373-8057Abstract The precise neural underpinnings of face pareidolia in patients with Parkinson’s disease (PD) remain unclear. We aimed to clarify face recognition network abnormalities associated with face pareidolia in such patients. Eighty-three patients with PD and 40 healthy controls were recruited in this study. Patients with PD were classified into pareidolia and nonpareidolia groups. Volumetric analyses revealed no significant differences between the pareidolia (n = 39) and nonpareidolia (n = 44) patient groups. We further observed decreased functional connectivity among regions of interest in the bilateral frontotemporal lobes in patients with pareidolia. Seed-based analysis using bilateral temporal fusiform cortices as seeds revealed significantly decreased connectivity with the bilateral inferior medial prefrontal cortices in the pareidolia group. Post hoc regression analysis further demonstrated that the severity of face pareidolia was negatively correlated with functional connectivity between the bilateral temporal fusiform and medial prefrontal cortices. Our findings suggest that top-down modulation of the face recognition network is impaired in patients with PD experiencing face pareidolia.Yuta KajiyamaNoriaki HattoriTomohito NakanoGajanan S. RevankarHironori OtomuneRyota HashimotoEtsuro MoriManabu IkedaMasahito MiharaHideki MochizukiNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Yuta Kajiyama Noriaki Hattori Tomohito Nakano Gajanan S. Revankar Hironori Otomune Ryota Hashimoto Etsuro Mori Manabu Ikeda Masahito Mihara Hideki Mochizuki Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
description	Abstract The precise neural underpinnings of face pareidolia in patients with Parkinson’s disease (PD) remain unclear. We aimed to clarify face recognition network abnormalities associated with face pareidolia in such patients. Eighty-three patients with PD and 40 healthy controls were recruited in this study. Patients with PD were classified into pareidolia and nonpareidolia groups. Volumetric analyses revealed no significant differences between the pareidolia (n = 39) and nonpareidolia (n = 44) patient groups. We further observed decreased functional connectivity among regions of interest in the bilateral frontotemporal lobes in patients with pareidolia. Seed-based analysis using bilateral temporal fusiform cortices as seeds revealed significantly decreased connectivity with the bilateral inferior medial prefrontal cortices in the pareidolia group. Post hoc regression analysis further demonstrated that the severity of face pareidolia was negatively correlated with functional connectivity between the bilateral temporal fusiform and medial prefrontal cortices. Our findings suggest that top-down modulation of the face recognition network is impaired in patients with PD experiencing face pareidolia.
format	article
author	Yuta Kajiyama Noriaki Hattori Tomohito Nakano Gajanan S. Revankar Hironori Otomune Ryota Hashimoto Etsuro Mori Manabu Ikeda Masahito Mihara Hideki Mochizuki
author_facet	Yuta Kajiyama Noriaki Hattori Tomohito Nakano Gajanan S. Revankar Hironori Otomune Ryota Hashimoto Etsuro Mori Manabu Ikeda Masahito Mihara Hideki Mochizuki
author_sort	Yuta Kajiyama
title	Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
title_short	Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
title_full	Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
title_fullStr	Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
title_full_unstemmed	Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
title_sort	decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f948faea33cf44cc9a1057dd2190bcd3
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Decreased frontotemporal connectivity in patients with parkinson’s disease experiencing face pareidolia

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