Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH

Abstract Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena – the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks....

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Autores principales:	Jelena Korać, Dalibor M. Stanković, Marina Stanić, Danica Bajuk-Bogdanović, Milan Žižić, Jelena Bogdanović Pristov, Sanja Grgurić-Šipka, Ana Popović-Bijelić, Ivan Spasojević
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f94a20e1818b4782ad745e960af83979
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spelling	oai:doaj.org-article:f94a20e1818b4782ad745e960af839792021-12-02T16:07:50ZCoordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH10.1038/s41598-018-21940-72045-2322https://doaj.org/article/f94a20e1818b4782ad745e960af839792018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21940-7https://doaj.org/toc/2045-2322Abstract Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena – the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O2 reduction, and to a facilitated formation of the Epi–Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.Jelena KoraćDalibor M. StankovićMarina StanićDanica Bajuk-BogdanovićMilan ŽižićJelena Bogdanović PristovSanja Grgurić-ŠipkaAna Popović-BijelićIvan SpasojevićNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jelena Korać Dalibor M. Stanković Marina Stanić Danica Bajuk-Bogdanović Milan Žižić Jelena Bogdanović Pristov Sanja Grgurić-Šipka Ana Popović-Bijelić Ivan Spasojević Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
description	Abstract Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena – the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O2 reduction, and to a facilitated formation of the Epi–Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.
format	article
author	Jelena Korać Dalibor M. Stanković Marina Stanić Danica Bajuk-Bogdanović Milan Žižić Jelena Bogdanović Pristov Sanja Grgurić-Šipka Ana Popović-Bijelić Ivan Spasojević
author_facet	Jelena Korać Dalibor M. Stanković Marina Stanić Danica Bajuk-Bogdanović Milan Žižić Jelena Bogdanović Pristov Sanja Grgurić-Šipka Ana Popović-Bijelić Ivan Spasojević
author_sort	Jelena Korać
title	Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
title_short	Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
title_full	Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
title_fullStr	Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
title_full_unstemmed	Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
title_sort	coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological ph
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f94a20e1818b4782ad745e960af83979
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Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH

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