METABOLISM

According to the World Health Organization experts, the prevalence of diabetes is ahead of the most pessimistic forecasts and has already acquired the character of non-infectious epidemic in the world. Furthermore, today there is a tendency not only to the increase in the incidence of type 2 diabete...

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Autores principales:	T. P. Bardymova, M. V. Mistyakov, O. V. Seurko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	frax diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d Science Q
Acceso en línea:	https://doaj.org/article/f94a21c8cdcc45e6bf57587784595550
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spelling	oai:doaj.org-article:f94a21c8cdcc45e6bf575877845955502021-11-23T06:14:37ZMETABOLISM2541-94202587-959610.12737/article_5955e6b426dd01.77009002https://doaj.org/article/f94a21c8cdcc45e6bf575877845955502017-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/354https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596According to the World Health Organization experts, the prevalence of diabetes is ahead of the most pessimistic forecasts and has already acquired the character of non-infectious epidemic in the world. Furthermore, today there is a tendency not only to the increase in the incidence of type 2 diabetes, but to the prevalence of comorbid conditions, including osteoporosis and osteopenia. In turn, in recent decades, osteoporosis is one of the most widespread and socially significant diseases, in all countries without exception its frequency in recent decades has been steadily increasing particularly among postmenopausal women. At the same time, a special state of bone metabolism in patients with type 2 diabetes is marked. The paper presents the study results of the content of the markers of bone metabolism in postmenopausal women with type 2 diabetes. Twenty-eight women, 15 of them with type 2 diabetes and 13 - in the control group were examined. The levels of ionized calcium, 25-OH vitamin D, osteocalcin, N-terminal propeptide of type 1 procollagen C-terminal telopeptides of type I collagen were determined. We also estimated the average daily calcium intake in women with type 2 diabetes. A substantial reduction in markers of bone metabolism, reflecting fixation processes, due to lower markers characterizing osteoresorption in patients with type 2 diabetes relative to the control group was determined. The findings raise the question of further studies of the mechanisms of formation of bone metabolism disorders in conditions of hyperglycemia.T. P. BardymovaM. V. MistyakovO. V. SeurkoScientific Сentre for Family Health and Human Reproduction Problemsarticlefraxdiabetes mellitusosteoporosisinsufficiency/deficiency of vitamin dfraxScienceQRUActa Biomedica Scientifica, Vol 2, Iss 1, Pp 16-18 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	frax diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d frax Science Q
spellingShingle	frax diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d frax Science Q T. P. Bardymova M. V. Mistyakov O. V. Seurko METABOLISM
description	According to the World Health Organization experts, the prevalence of diabetes is ahead of the most pessimistic forecasts and has already acquired the character of non-infectious epidemic in the world. Furthermore, today there is a tendency not only to the increase in the incidence of type 2 diabetes, but to the prevalence of comorbid conditions, including osteoporosis and osteopenia. In turn, in recent decades, osteoporosis is one of the most widespread and socially significant diseases, in all countries without exception its frequency in recent decades has been steadily increasing particularly among postmenopausal women. At the same time, a special state of bone metabolism in patients with type 2 diabetes is marked. The paper presents the study results of the content of the markers of bone metabolism in postmenopausal women with type 2 diabetes. Twenty-eight women, 15 of them with type 2 diabetes and 13 - in the control group were examined. The levels of ionized calcium, 25-OH vitamin D, osteocalcin, N-terminal propeptide of type 1 procollagen C-terminal telopeptides of type I collagen were determined. We also estimated the average daily calcium intake in women with type 2 diabetes. A substantial reduction in markers of bone metabolism, reflecting fixation processes, due to lower markers characterizing osteoresorption in patients with type 2 diabetes relative to the control group was determined. The findings raise the question of further studies of the mechanisms of formation of bone metabolism disorders in conditions of hyperglycemia.
format	article
author	T. P. Bardymova M. V. Mistyakov O. V. Seurko
author_facet	T. P. Bardymova M. V. Mistyakov O. V. Seurko
author_sort	T. P. Bardymova
title	METABOLISM
title_short	METABOLISM
title_full	METABOLISM
title_fullStr	METABOLISM
title_full_unstemmed	METABOLISM
title_sort	metabolism
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/f94a21c8cdcc45e6bf57587784595550
work_keys_str_mv	AT tpbardymova metabolism AT mvmistyakov metabolism AT ovseurko metabolism
_version_	1718417047741792256

METABOLISM

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