Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia

Cristina Domenech,1,2 Adriana Pastore,3 A Carlo Altamura,4 Corrado Bernasconi,5 Ricardo Corral,6 Helio Elkis,7 Jonathan Evans,8 Ashok Malla,9 Francesco Margari,3 Marie-Odile Krebs,10 Anna-Lena Nordstroem,5 Mathias Zink,11 Josep Maria Haro1,2 1Universitat de Barcelona, Barcelona, Spain; 2Parc Sanitar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Domenech C, Pastore A, Altamura AC, Bernasconi C, Corral R, Elkis H, Evans J, Malla A, Margari F, Krebs MO, Nordstroem AL, Zink M, Haro JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	schizophrenia health-related quality of life epidemiology persistent symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f94a265fc5ef4541b5d87dc25ae538c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f94a265fc5ef4541b5d87dc25ae538c5
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia health-related quality of life epidemiology persistent symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia health-related quality of life epidemiology persistent symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Domenech C Pastore A Altamura AC Bernasconi C Corral R Elkis H Evans J Malla A Margari F Krebs MO Nordstroem AL Zink M Haro JM Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
description	Cristina Domenech,1,2 Adriana Pastore,3 A Carlo Altamura,4 Corrado Bernasconi,5 Ricardo Corral,6 Helio Elkis,7 Jonathan Evans,8 Ashok Malla,9 Francesco Margari,3 Marie-Odile Krebs,10 Anna-Lena Nordstroem,5 Mathias Zink,11 Josep Maria Haro1,2 1Universitat de Barcelona, Barcelona, Spain; 2Parc Sanitari Sant Joan de Déu, CIBERSAM, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; 3Department of Basic Medical Science, Neuroscience and Sense Organs, ‘Policlinico’ Hospital, University of Bari ‘Aldo Moro’, Bari, Italy; 4University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy; 5F. Hoffmann-La Roche Ltd, Basel, Switzerland; 6Fundación para el Estudio y Tratamiento de las Enfermedades Mentales (FETEM), Buenos Aires, Argentina; 7Departamento e Instituto de Psiquiatria – FMUSP, Sao Paulo, Brazil; 8Centre for Academic Mental Health, University of Bristol, Bristol, UK; 9Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada; 10Service Hospitalo Universitaire, Laboratoire de Physiopathologie des Maladies Psychiatriques, Inserm, Université Paris Descartes, Hôpital Sainte-Anne, Paris, France; 11Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany and Regional Clinical Centre, Ansbach, GermanyCorrespondence: Josep Maria HaroParc Sanitari Sant Joan de Déu - Antoni Pujadas, 42 - 08830 Sant Boi de Llobregat, Barcelona, SpainTel +34 93 600 26 85Email jmharo@pssjd.orgBackground: Generic health-related quality of life (HRQoL) scales are increasingly being used to assess the effects of new treatments in schizophrenia. The objective of this study is to better understand the usefulness of generic and condition specific HRQoL scales in schizophrenia by analyzing their correlates.Methods: Data formed part of the Pattern study, an international observational study among 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia (CGI-SCH) Scale and the Positive and Negative Syndrome Scale (PANSS) and reported their HRQoL using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D). The two summary values of the SF-36 (the Mental Component Score and the Physical Component Score, SF-36 MCS and SF-36 PCS) were calculated.Results: Higher PANSS positive dimension ratings were associated with worse HRQoL for the SQLS, EQ-5D VAS, SF-36 MCS, and SF-36 PCS. Higher PANSS negative dimension ratings were associated with worse HRQoL for the EQ-5D VAS, SF-36 MCS, and SF-36 PCS, but not for the SQLS or the EQ-5D tariff. PANSS depression ratings were associated with lower HRQoL in all the scales. There was a high correlation between the HRQoL scales. However, in patients with more severe cognitive/disorganized PANSS symptoms, the SQLS score was relatively higher than the EQ-5D tariff and SF-36 PCS scores.Conclusion: This study has shown substantial agreement between three HRQoL scales, being either generic or condition specific. This supports the use of generic HRQoL measures in schizophrenia.Clinicaltrials.gov identifier: NCT01634542 (July 6, 2012, retrospectively registered).Keywords: schizophrenia, health-related quality of life, epidemiology, persistent symptoms
format	article
author	Domenech C Pastore A Altamura AC Bernasconi C Corral R Elkis H Evans J Malla A Margari F Krebs MO Nordstroem AL Zink M Haro JM
author_facet	Domenech C Pastore A Altamura AC Bernasconi C Corral R Elkis H Evans J Malla A Margari F Krebs MO Nordstroem AL Zink M Haro JM
author_sort	Domenech C
title	Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
title_short	Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
title_full	Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
title_fullStr	Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
title_full_unstemmed	Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia
title_sort	correlation of health-related quality of life in clinically stable outpatients with schizophrenia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f94a265fc5ef4541b5d87dc25ae538c5
work_keys_str_mv	AT domenechc correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT pastorea correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT altamuraac correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT bernasconic correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT corralr correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT elkish correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT evansj correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT mallaa correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT margarif correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT krebsmo correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT nordstroemal correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT zinkm correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia AT harojm correlationofhealthrelatedqualityoflifeinclinicallystableoutpatientswithschizophrenia
_version_	1718400330722443264
spelling	oai:doaj.org-article:f94a265fc5ef4541b5d87dc25ae538c52021-12-02T05:36:46ZCorrelation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia1178-2021https://doaj.org/article/f94a265fc5ef4541b5d87dc25ae538c52019-12-01T00:00:00Zhttps://www.dovepress.com/correlation-of-health-related-quality-of-life-in-clinically-stable-out-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Cristina Domenech,1,2 Adriana Pastore,3 A Carlo Altamura,4 Corrado Bernasconi,5 Ricardo Corral,6 Helio Elkis,7 Jonathan Evans,8 Ashok Malla,9 Francesco Margari,3 Marie-Odile Krebs,10 Anna-Lena Nordstroem,5 Mathias Zink,11 Josep Maria Haro1,2 1Universitat de Barcelona, Barcelona, Spain; 2Parc Sanitari Sant Joan de Déu, CIBERSAM, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; 3Department of Basic Medical Science, Neuroscience and Sense Organs, ‘Policlinico’ Hospital, University of Bari ‘Aldo Moro’, Bari, Italy; 4University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy; 5F. Hoffmann-La Roche Ltd, Basel, Switzerland; 6Fundación para el Estudio y Tratamiento de las Enfermedades Mentales (FETEM), Buenos Aires, Argentina; 7Departamento e Instituto de Psiquiatria – FMUSP, Sao Paulo, Brazil; 8Centre for Academic Mental Health, University of Bristol, Bristol, UK; 9Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada; 10Service Hospitalo Universitaire, Laboratoire de Physiopathologie des Maladies Psychiatriques, Inserm, Université Paris Descartes, Hôpital Sainte-Anne, Paris, France; 11Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany and Regional Clinical Centre, Ansbach, GermanyCorrespondence: Josep Maria HaroParc Sanitari Sant Joan de Déu - Antoni Pujadas, 42 - 08830 Sant Boi de Llobregat, Barcelona, SpainTel +34 93 600 26 85Email jmharo@pssjd.orgBackground: Generic health-related quality of life (HRQoL) scales are increasingly being used to assess the effects of new treatments in schizophrenia. The objective of this study is to better understand the usefulness of generic and condition specific HRQoL scales in schizophrenia by analyzing their correlates.Methods: Data formed part of the Pattern study, an international observational study among 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia (CGI-SCH) Scale and the Positive and Negative Syndrome Scale (PANSS) and reported their HRQoL using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D). The two summary values of the SF-36 (the Mental Component Score and the Physical Component Score, SF-36 MCS and SF-36 PCS) were calculated.Results: Higher PANSS positive dimension ratings were associated with worse HRQoL for the SQLS, EQ-5D VAS, SF-36 MCS, and SF-36 PCS. Higher PANSS negative dimension ratings were associated with worse HRQoL for the EQ-5D VAS, SF-36 MCS, and SF-36 PCS, but not for the SQLS or the EQ-5D tariff. PANSS depression ratings were associated with lower HRQoL in all the scales. There was a high correlation between the HRQoL scales. However, in patients with more severe cognitive/disorganized PANSS symptoms, the SQLS score was relatively higher than the EQ-5D tariff and SF-36 PCS scores.Conclusion: This study has shown substantial agreement between three HRQoL scales, being either generic or condition specific. This supports the use of generic HRQoL measures in schizophrenia.Clinicaltrials.gov identifier: NCT01634542 (July 6, 2012, retrospectively registered).Keywords: schizophrenia, health-related quality of life, epidemiology, persistent symptomsDomenech CPastore AAltamura ACBernasconi CCorral RElkis HEvans JMalla AMargari FKrebs MONordstroem ALZink MHaro JMDove Medical Pressarticleschizophreniahealth-related quality of lifeepidemiologypersistent symptomsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3475-3486 (2019)

Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia

Ejemplares similares