Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein

Age-related deterioration of sensorimotor and cognitive abilities suggests that the brain undergoes regressive alterations with aging that compromise its function. Thus, the present study was designed to assess the efficacy of Dunaliella salina in counteracting D-galactose (D-gal)-induced dementia b...

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Autores principales:	Farouk K. El-Baz, Gehad A. Abdel Jaleel, Rehab A. Hussein, Dalia O. Saleh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Dunalialla salina Aging Dementia Amyloid-β protein Neurotransmitters Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/f94b93071fd444c79688fb2ffeca0b46
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spelling	oai:doaj.org-article:f94b93071fd444c79688fb2ffeca0b462021-12-04T04:34:22ZDunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein2214-750010.1016/j.toxrep.2021.11.021https://doaj.org/article/f94b93071fd444c79688fb2ffeca0b462021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214750021002055https://doaj.org/toc/2214-7500Age-related deterioration of sensorimotor and cognitive abilities suggests that the brain undergoes regressive alterations with aging that compromise its function. Thus, the present study was designed to assess the efficacy of Dunaliella salina in counteracting D-galactose (D-gal)-induced dementia brain aging and its modulatory role in attenuating amyloid β (Aβ) protein and neurotransmitters. Aging associated dementia was generated by injection of D-gal (200 mg/kg; i.p) of rats for 8 weeks. D. salina biomass (250 mg/kg), polar (30 mg/kg), its carotenoid (30 mg/kg) fractions as well as the isolated zeaxanthin (250 μg/kg) were given orally simultaneously with D-gal for additional two weeks. Twenty-four hours after the last treatment dose; behavioral, biochemical and histopathological assessment were performed. Results showed that oral treatment of motor deficit rats with D. salina biomass and its isolated polar and carotenoid fractions showed amelioration in the motor coordination assessed by the rotarod test and in the memory and learning capabilities evaluated by Morris water maze test. D. salina also showed a reduction in brain levels of inflammatory indicators viz. interlekin-1β and inducible nitric oxide synthetase as well as brain contents of Aβ protein and myelin base protein. Likewise, oral treatment with D. salina biomass and its isolated polar and carotenoid fractions exhibited an increase in the rats’ brain neurotransmitters and their metabolites. Furthermore, histopathological investigations have confirmed all of these results. Our findings suggest that D. salina overcomes brain aging and thereby repairs age-related dementia, both for its modulating function in attenuating the Aβ protein and neurotransmitters.Farouk K. El-BazGehad A. Abdel JaleelRehab A. HusseinDalia O. SalehElsevierarticleDunalialla salinaAgingDementiaAmyloid-β proteinNeurotransmittersToxicology. PoisonsRA1190-1270ENToxicology Reports, Vol 8, Iss , Pp 1899-1908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dunalialla salina Aging Dementia Amyloid-β protein Neurotransmitters Toxicology. Poisons RA1190-1270
spellingShingle	Dunalialla salina Aging Dementia Amyloid-β protein Neurotransmitters Toxicology. Poisons RA1190-1270 Farouk K. El-Baz Gehad A. Abdel Jaleel Rehab A. Hussein Dalia O. Saleh Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
description	Age-related deterioration of sensorimotor and cognitive abilities suggests that the brain undergoes regressive alterations with aging that compromise its function. Thus, the present study was designed to assess the efficacy of Dunaliella salina in counteracting D-galactose (D-gal)-induced dementia brain aging and its modulatory role in attenuating amyloid β (Aβ) protein and neurotransmitters. Aging associated dementia was generated by injection of D-gal (200 mg/kg; i.p) of rats for 8 weeks. D. salina biomass (250 mg/kg), polar (30 mg/kg), its carotenoid (30 mg/kg) fractions as well as the isolated zeaxanthin (250 μg/kg) were given orally simultaneously with D-gal for additional two weeks. Twenty-four hours after the last treatment dose; behavioral, biochemical and histopathological assessment were performed. Results showed that oral treatment of motor deficit rats with D. salina biomass and its isolated polar and carotenoid fractions showed amelioration in the motor coordination assessed by the rotarod test and in the memory and learning capabilities evaluated by Morris water maze test. D. salina also showed a reduction in brain levels of inflammatory indicators viz. interlekin-1β and inducible nitric oxide synthetase as well as brain contents of Aβ protein and myelin base protein. Likewise, oral treatment with D. salina biomass and its isolated polar and carotenoid fractions exhibited an increase in the rats’ brain neurotransmitters and their metabolites. Furthermore, histopathological investigations have confirmed all of these results. Our findings suggest that D. salina overcomes brain aging and thereby repairs age-related dementia, both for its modulating function in attenuating the Aβ protein and neurotransmitters.
format	article
author	Farouk K. El-Baz Gehad A. Abdel Jaleel Rehab A. Hussein Dalia O. Saleh
author_facet	Farouk K. El-Baz Gehad A. Abdel Jaleel Rehab A. Hussein Dalia O. Saleh
author_sort	Farouk K. El-Baz
title	Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
title_short	Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
title_full	Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
title_fullStr	Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
title_full_unstemmed	Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein
title_sort	dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: modulation of neurotransmission and amyloid-β protein
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f94b93071fd444c79688fb2ffeca0b46
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Dunalialla salina microalgea and its isolated zeaxanthin mitigate age-related dementia in rats: Modulation of neurotransmission and amyloid-β protein

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