Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity

Abstract Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katie M. Harris, Lonnie G. Petersen, Tobias Weber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/f94c28a24b404e15b0444eb98e2ffe15
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f94c28a24b404e15b0444eb98e2ffe15
record_format	dspace
spelling	oai:doaj.org-article:f94c28a24b404e15b0444eb98e2ffe152021-12-02T13:56:10ZReviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity10.1038/s41526-020-00127-32373-8065https://doaj.org/article/f94c28a24b404e15b0444eb98e2ffe152020-12-01T00:00:00Zhttps://doi.org/10.1038/s41526-020-00127-3https://doaj.org/toc/2373-8065Abstract Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.Katie M. HarrisLonnie G. PetersenTobias WeberNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 6, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Katie M. Harris Lonnie G. Petersen Tobias Weber Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
description	Abstract Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.
format	article
author	Katie M. Harris Lonnie G. Petersen Tobias Weber
author_facet	Katie M. Harris Lonnie G. Petersen Tobias Weber
author_sort	Katie M. Harris
title	Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
title_short	Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
title_full	Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
title_fullStr	Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
title_full_unstemmed	Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
title_sort	reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f94c28a24b404e15b0444eb98e2ffe15
work_keys_str_mv	AT katiemharris revivinglowerbodynegativepressureasacountermeasuretopreventpathologicalvascularandocularchangesinmicrogravity AT lonniegpetersen revivinglowerbodynegativepressureasacountermeasuretopreventpathologicalvascularandocularchangesinmicrogravity AT tobiasweber revivinglowerbodynegativepressureasacountermeasuretopreventpathologicalvascularandocularchangesinmicrogravity
_version_	1718392415771951104

Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity

Ejemplares similares