Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.

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Autores principales:	Michael D. Kessler, Laura Yerges-Armstrong, Margaret A. Taub, Amol C. Shetty, Kristin Maloney, Linda Jo Bone Jeng, Ingo Ruczinski, Albert M. Levin, L. Keoki Williams, Terri H. Beaty, Rasika A. Mathias, Kathleen C. Barnes, Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), Timothy D. O’Connor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9576b534da64e5a9b33c002e1f226f9
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spelling	oai:doaj.org-article:f9576b534da64e5a9b33c002e1f226f92021-12-02T17:31:32ZChallenges and disparities in the application of personalized genomic medicine to populations with African ancestry10.1038/ncomms125212041-1723https://doaj.org/article/f9576b534da64e5a9b33c002e1f226f92016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12521https://doaj.org/toc/2041-1723Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.Michael D. KesslerLaura Yerges-ArmstrongMargaret A. TaubAmol C. ShettyKristin MaloneyLinda Jo Bone JengIngo RuczinskiAlbert M. LevinL. Keoki WilliamsTerri H. BeatyRasika A. MathiasKathleen C. BarnesConsortium on Asthma among African-ancestry Populations in the Americas (CAAPA)Timothy D. O’ConnorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael D. Kessler Laura Yerges-Armstrong Margaret A. Taub Amol C. Shetty Kristin Maloney Linda Jo Bone Jeng Ingo Ruczinski Albert M. Levin L. Keoki Williams Terri H. Beaty Rasika A. Mathias Kathleen C. Barnes Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) Timothy D. O’Connor Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
description	Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.
format	article
author	Michael D. Kessler Laura Yerges-Armstrong Margaret A. Taub Amol C. Shetty Kristin Maloney Linda Jo Bone Jeng Ingo Ruczinski Albert M. Levin L. Keoki Williams Terri H. Beaty Rasika A. Mathias Kathleen C. Barnes Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) Timothy D. O’Connor
author_facet	Michael D. Kessler Laura Yerges-Armstrong Margaret A. Taub Amol C. Shetty Kristin Maloney Linda Jo Bone Jeng Ingo Ruczinski Albert M. Levin L. Keoki Williams Terri H. Beaty Rasika A. Mathias Kathleen C. Barnes Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) Timothy D. O’Connor
author_sort	Michael D. Kessler
title	Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
title_short	Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
title_full	Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
title_fullStr	Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
title_full_unstemmed	Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
title_sort	challenges and disparities in the application of personalized genomic medicine to populations with african ancestry
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f9576b534da64e5a9b33c002e1f226f9
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Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

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