Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients

Exclusive enteral nutrition (EEN) is a first-line treatment in active, mild to moderate Crohn’s disease (CD) in children. The Crohn’s disease exclusion diet (CDED), which avoids products known to have a pro-inflammatory effect on the intestinal mucosa, presents similar effectiveness to EEN for induc...

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Autores principales:	Martyna Szczubełek, Karolina Pomorska, Monika Korólczyk-Kowalczyk, Konrad Lewandowski, Magdalena Kaniewska, Grażyna Rydzewska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Crohn’s disease Crohn’s disease exclusion diet dietary therapy Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f957b921b2784ea1956bfb6020f32566
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spelling	oai:doaj.org-article:f957b921b2784ea1956bfb6020f325662021-11-25T18:36:51ZEffectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients10.3390/nu131141122072-6643https://doaj.org/article/f957b921b2784ea1956bfb6020f325662021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4112https://doaj.org/toc/2072-6643Exclusive enteral nutrition (EEN) is a first-line treatment in active, mild to moderate Crohn’s disease (CD) in children. The Crohn’s disease exclusion diet (CDED), which avoids products known to have a pro-inflammatory effect on the intestinal mucosa, presents similar effectiveness to EEN for inducing remission in the paediatric population. The aim of the study was to evaluate the effectiveness of the CDED in inducing remission in adult patients. Between March 2020 and May 2021, 32 patients in a gastroenterology outpatient centre were treated according to the assumptions of the CDED. The patients were seen at baseline, at week 6, and at week 12 of the study. During the visits, anthropometric measurements and laboratory tests were performed, Crohn’s disease activity index (CDAI) was calculated, and the Inflammatory Bowel Disease Questionnaire (IBDQ) was completed. The study included a total of 32 participants, 18 women (56.3%) and 14 men (43.7%). Clinical remission was obtained in 76.7% patients after 6 weeks and in 82.1% after 12 weeks of therapy. Calprotectin levels were significantly lower in the second follow-up compared with baseline (<i>p</i> = 0.021). The CDED is an effective therapy for inducing remission in the adult CD population.Martyna SzczubełekKarolina PomorskaMonika Korólczyk-KowalczykKonrad LewandowskiMagdalena KaniewskaGrażyna RydzewskaMDPI AGarticleCrohn’s diseaseCrohn’s disease exclusion dietdietary therapyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4112, p 4112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crohn’s disease Crohn’s disease exclusion diet dietary therapy Nutrition. Foods and food supply TX341-641
spellingShingle	Crohn’s disease Crohn’s disease exclusion diet dietary therapy Nutrition. Foods and food supply TX341-641 Martyna Szczubełek Karolina Pomorska Monika Korólczyk-Kowalczyk Konrad Lewandowski Magdalena Kaniewska Grażyna Rydzewska Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
description	Exclusive enteral nutrition (EEN) is a first-line treatment in active, mild to moderate Crohn’s disease (CD) in children. The Crohn’s disease exclusion diet (CDED), which avoids products known to have a pro-inflammatory effect on the intestinal mucosa, presents similar effectiveness to EEN for inducing remission in the paediatric population. The aim of the study was to evaluate the effectiveness of the CDED in inducing remission in adult patients. Between March 2020 and May 2021, 32 patients in a gastroenterology outpatient centre were treated according to the assumptions of the CDED. The patients were seen at baseline, at week 6, and at week 12 of the study. During the visits, anthropometric measurements and laboratory tests were performed, Crohn’s disease activity index (CDAI) was calculated, and the Inflammatory Bowel Disease Questionnaire (IBDQ) was completed. The study included a total of 32 participants, 18 women (56.3%) and 14 men (43.7%). Clinical remission was obtained in 76.7% patients after 6 weeks and in 82.1% after 12 weeks of therapy. Calprotectin levels were significantly lower in the second follow-up compared with baseline (<i>p</i> = 0.021). The CDED is an effective therapy for inducing remission in the adult CD population.
format	article
author	Martyna Szczubełek Karolina Pomorska Monika Korólczyk-Kowalczyk Konrad Lewandowski Magdalena Kaniewska Grażyna Rydzewska
author_facet	Martyna Szczubełek Karolina Pomorska Monika Korólczyk-Kowalczyk Konrad Lewandowski Magdalena Kaniewska Grażyna Rydzewska
author_sort	Martyna Szczubełek
title	Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
title_short	Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
title_full	Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
title_fullStr	Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
title_full_unstemmed	Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients
title_sort	effectiveness of crohn’s disease exclusion diet for induction of remission in crohn’s disease adult patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f957b921b2784ea1956bfb6020f32566
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Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients

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