Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Polygenic scores are believed to hold future promise for trait prediction and personalized medicine, but are sensitive to demographic history. Here, Marnetto et al. develop partial polygenic scores supplemented with local ancestry deconvolution which improves prediction accuracy into recently admixe...

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Bibliographic Details
Main Authors: Davide Marnetto, Katri Pärna, Kristi Läll, Ludovica Molinaro, Francesco Montinaro, Toomas Haller, Mait Metspalu, Reedik Mägi, Krista Fischer, Luca Pagani
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/f95c60326b1a4da89c378b225bf30d78
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