HIF-2α is indispensable for regulatory T cell function

HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression and is critical for Treg cell function.

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Autores principales:	Tzu-Sheng Hsu, Yen-Lin Lin, Yu-An Wang, Shu-Ting Mo, Po-Yu Chi, Alan Chuan-Ying Lai, Hsuan-Yin Pan, Ya-Jen Chang, Ming-Zong Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f95d5dd1646242e19c8c1bf174725c4d
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spelling	oai:doaj.org-article:f95d5dd1646242e19c8c1bf174725c4d2021-12-02T17:13:19ZHIF-2α is indispensable for regulatory T cell function10.1038/s41467-020-18731-y2041-1723https://doaj.org/article/f95d5dd1646242e19c8c1bf174725c4d2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18731-yhttps://doaj.org/toc/2041-1723HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression and is critical for Treg cell function.Tzu-Sheng HsuYen-Lin LinYu-An WangShu-Ting MoPo-Yu ChiAlan Chuan-Ying LaiHsuan-Yin PanYa-Jen ChangMing-Zong LaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tzu-Sheng Hsu Yen-Lin Lin Yu-An Wang Shu-Ting Mo Po-Yu Chi Alan Chuan-Ying Lai Hsuan-Yin Pan Ya-Jen Chang Ming-Zong Lai HIF-2α is indispensable for regulatory T cell function
description	HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression and is critical for Treg cell function.
format	article
author	Tzu-Sheng Hsu Yen-Lin Lin Yu-An Wang Shu-Ting Mo Po-Yu Chi Alan Chuan-Ying Lai Hsuan-Yin Pan Ya-Jen Chang Ming-Zong Lai
author_facet	Tzu-Sheng Hsu Yen-Lin Lin Yu-An Wang Shu-Ting Mo Po-Yu Chi Alan Chuan-Ying Lai Hsuan-Yin Pan Ya-Jen Chang Ming-Zong Lai
author_sort	Tzu-Sheng Hsu
title	HIF-2α is indispensable for regulatory T cell function
title_short	HIF-2α is indispensable for regulatory T cell function
title_full	HIF-2α is indispensable for regulatory T cell function
title_fullStr	HIF-2α is indispensable for regulatory T cell function
title_full_unstemmed	HIF-2α is indispensable for regulatory T cell function
title_sort	hif-2α is indispensable for regulatory t cell function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f95d5dd1646242e19c8c1bf174725c4d
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HIF-2α is indispensable for regulatory T cell function

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