Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study

Abstract We investigated localization and safe resection margins for breast cancer patients undergoing breast conserving surgery (BCS) using ultrasound-guided indocyanine green fluorescence (ICG-F) marking. From April 2016 to March 2019, we prospectively enrolled 114 patients who underwent BCS using...

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Autores principales:	Eun-Gyeong Lee, Seok-Ki Kim, Jai Hong Han, Dong-Eun Lee, So-Youn Jung, Seeyoun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f95f7c4ec04b4c128ddbf3b26587ce9d
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spelling	oai:doaj.org-article:f95f7c4ec04b4c128ddbf3b26587ce9d2021-12-02T15:36:13ZSurgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study10.1038/s41598-021-89423-w2045-2322https://doaj.org/article/f95f7c4ec04b4c128ddbf3b26587ce9d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89423-whttps://doaj.org/toc/2045-2322Abstract We investigated localization and safe resection margins for breast cancer patients undergoing breast conserving surgery (BCS) using ultrasound-guided indocyanine green fluorescence (ICG-F) marking. From April 2016 to March 2019, we prospectively enrolled 114 patients who underwent BCS using US-guided ICG-F marking and we compared these results with 300 patients who underwent BCS using US-guided skin marking from January 2012 to December 2016. Clinical features, identification rates, status of resection margins, and re-operation rates were analyzed. The ICG-F identification rate was 100% (114/114). The mean approach time for resection of the lesion ICG-F using group was about 13 min. The positive rate of frozen resection margins was 10.5% using ICG-F and 25.0% using sono-guided skin marking (p < 0.01). The rate of additional intraoperative resection was significantly lower in the ICG-F marking group compared to that in the sono-guided skin marking group (8.8% vs. 23.3%, p < 0.01). The rate of final positive resection margins was 3.5% in the ICG-F using group and 14.7% in the sono-guided skin marking group (p < 0.01). The rate of re-operation was 4.4% in the ICG-F using group and 4% in the sono-guided group (p = 0.79). At follow-up after the operation using ICG-F, no complications occurred. Using ICG-F during BCS could be a safe, sophisticated method for localization.Eun-Gyeong LeeSeok-Ki KimJai Hong HanDong-Eun LeeSo-Youn JungSeeyoun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun-Gyeong Lee Seok-Ki Kim Jai Hong Han Dong-Eun Lee So-Youn Jung Seeyoun Lee Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
description	Abstract We investigated localization and safe resection margins for breast cancer patients undergoing breast conserving surgery (BCS) using ultrasound-guided indocyanine green fluorescence (ICG-F) marking. From April 2016 to March 2019, we prospectively enrolled 114 patients who underwent BCS using US-guided ICG-F marking and we compared these results with 300 patients who underwent BCS using US-guided skin marking from January 2012 to December 2016. Clinical features, identification rates, status of resection margins, and re-operation rates were analyzed. The ICG-F identification rate was 100% (114/114). The mean approach time for resection of the lesion ICG-F using group was about 13 min. The positive rate of frozen resection margins was 10.5% using ICG-F and 25.0% using sono-guided skin marking (p < 0.01). The rate of additional intraoperative resection was significantly lower in the ICG-F marking group compared to that in the sono-guided skin marking group (8.8% vs. 23.3%, p < 0.01). The rate of final positive resection margins was 3.5% in the ICG-F using group and 14.7% in the sono-guided skin marking group (p < 0.01). The rate of re-operation was 4.4% in the ICG-F using group and 4% in the sono-guided group (p = 0.79). At follow-up after the operation using ICG-F, no complications occurred. Using ICG-F during BCS could be a safe, sophisticated method for localization.
format	article
author	Eun-Gyeong Lee Seok-Ki Kim Jai Hong Han Dong-Eun Lee So-Youn Jung Seeyoun Lee
author_facet	Eun-Gyeong Lee Seok-Ki Kim Jai Hong Han Dong-Eun Lee So-Youn Jung Seeyoun Lee
author_sort	Eun-Gyeong Lee
title	Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
title_short	Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
title_full	Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
title_fullStr	Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
title_full_unstemmed	Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
title_sort	surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f95f7c4ec04b4c128ddbf3b26587ce9d
work_keys_str_mv	AT eungyeonglee surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy AT seokkikim surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy AT jaihonghan surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy AT dongeunlee surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy AT soyounjung surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy AT seeyounlee surgicaloutcomesoflocalizationusingindocyaninegreenfluorescenceinbreastconservingsurgeryaprospectivestudy
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Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study

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