Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study

Abstract Little is known about the comorbidities in actinic keratosis patients. To evaluate the association of actinic keratosis with certain malignancies. All patients with actinic keratosis (n = 61,438) and age- and sex-matched control subjects (n = 307,190) at a 5:1 ratio were enrolled using data...

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Autores principales:	Young Bok Lee, Ji Hyun Lee, Yeong Ho Kim, Ji Min Seo, Dong Soo Yu, Yong Gyu Park, Kyung Do Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9618e56b45c45b6b57d6cb3b46ef5f6
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spelling	oai:doaj.org-article:f9618e56b45c45b6b57d6cb3b46ef5f62021-12-02T16:56:43ZPositive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study10.1038/s41598-021-99225-92045-2322https://doaj.org/article/f9618e56b45c45b6b57d6cb3b46ef5f62021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99225-9https://doaj.org/toc/2045-2322Abstract Little is known about the comorbidities in actinic keratosis patients. To evaluate the association of actinic keratosis with certain malignancies. All patients with actinic keratosis (n = 61,438) and age- and sex-matched control subjects (n = 307,190) at a 5:1 ratio were enrolled using data from the Korean National Health Insurance Service between the years 2007 and 2014. In subjects with actinic keratosis, overall cancer incidence was higher than that for controls after income level, habitat, diabetes, hypertension, and dyslipidemia were adjusted (Hazard Ratio [HR] = 1.43 [95% confidence interval 1.38–1.47]). The positive association of specific cancers were observed in the following order: skin cancer (HR = 3.43 [2.47–4.75]), oral cavity and pharyngeal cancer (HR = 1.99 [1.57–2.52]), lymphoma (HR = 1.59 [1.28–1.96]), leukemia (HR = 1.35 [1.03–1.77]), prostate cancer (HR = 1.35 [1.21–1.51]), renal cancer (HR = 1.29 [1.02–1.63]), liver cancer (HR = 1.21 [1.09–1.35]), thyroid cancer (HR = 1.20 [1.05–1.38]), and gastric cancer (HR = 1.13 [1.03–1.23]). Although further research on pathologic mechanism is needed, the implications of a positive correlation between actinic keratosis and internal organ malignancies has great significance.Young Bok LeeJi Hyun LeeYeong Ho KimJi Min SeoDong Soo YuYong Gyu ParkKyung Do HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Bok Lee Ji Hyun Lee Yeong Ho Kim Ji Min Seo Dong Soo Yu Yong Gyu Park Kyung Do Han Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
description	Abstract Little is known about the comorbidities in actinic keratosis patients. To evaluate the association of actinic keratosis with certain malignancies. All patients with actinic keratosis (n = 61,438) and age- and sex-matched control subjects (n = 307,190) at a 5:1 ratio were enrolled using data from the Korean National Health Insurance Service between the years 2007 and 2014. In subjects with actinic keratosis, overall cancer incidence was higher than that for controls after income level, habitat, diabetes, hypertension, and dyslipidemia were adjusted (Hazard Ratio [HR] = 1.43 [95% confidence interval 1.38–1.47]). The positive association of specific cancers were observed in the following order: skin cancer (HR = 3.43 [2.47–4.75]), oral cavity and pharyngeal cancer (HR = 1.99 [1.57–2.52]), lymphoma (HR = 1.59 [1.28–1.96]), leukemia (HR = 1.35 [1.03–1.77]), prostate cancer (HR = 1.35 [1.21–1.51]), renal cancer (HR = 1.29 [1.02–1.63]), liver cancer (HR = 1.21 [1.09–1.35]), thyroid cancer (HR = 1.20 [1.05–1.38]), and gastric cancer (HR = 1.13 [1.03–1.23]). Although further research on pathologic mechanism is needed, the implications of a positive correlation between actinic keratosis and internal organ malignancies has great significance.
format	article
author	Young Bok Lee Ji Hyun Lee Yeong Ho Kim Ji Min Seo Dong Soo Yu Yong Gyu Park Kyung Do Han
author_facet	Young Bok Lee Ji Hyun Lee Yeong Ho Kim Ji Min Seo Dong Soo Yu Yong Gyu Park Kyung Do Han
author_sort	Young Bok Lee
title	Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
title_short	Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
title_full	Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
title_fullStr	Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
title_full_unstemmed	Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
title_sort	positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9618e56b45c45b6b57d6cb3b46ef5f6
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Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study

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