Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.

<h4>Background</h4>Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs135...

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Autores principales:	Martin Aasbrenn, Mathilde Svendstrup, Theresia M Schnurr, Dorte Lindqvist Hansen, Dorte Worm, Marie Balslev-Harder, Niels Grarup, Kristoffer Sølvsten Burgdorf, Henrik Vestergaard, Oluf Pedersen, Lars Ängquist, Mogens Fenger, Thorkild I A Sørensen, Sten Madsbad, Torben Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f964dd36b8994f65a3720e2fb3fd45fd
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spelling	oai:doaj.org-article:f964dd36b8994f65a3720e2fb3fd45fd2021-12-02T20:11:11ZGenetic markers of abdominal obesity and weight loss after gastric bypass surgery.1932-620310.1371/journal.pone.0252525https://doaj.org/article/f964dd36b8994f65a3720e2fb3fd45fd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252525https://doaj.org/toc/1932-6203<h4>Background</h4>Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.<h4>Methods</h4>Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.<h4>Results</h4>The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).<h4>Discussion</h4>GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.Martin AasbrennMathilde SvendstrupTheresia M SchnurrDorte Lindqvist HansenDorte WormMarie Balslev-HarderNiels GrarupKristoffer Sølvsten BurgdorfHenrik VestergaardOluf PedersenLars ÄngquistMogens FengerThorkild I A SørensenSten MadsbadTorben HansenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252525 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Aasbrenn Mathilde Svendstrup Theresia M Schnurr Dorte Lindqvist Hansen Dorte Worm Marie Balslev-Harder Niels Grarup Kristoffer Sølvsten Burgdorf Henrik Vestergaard Oluf Pedersen Lars Ängquist Mogens Fenger Thorkild I A Sørensen Sten Madsbad Torben Hansen Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
description	<h4>Background</h4>Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.<h4>Methods</h4>Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.<h4>Results</h4>The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).<h4>Discussion</h4>GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.
format	article
author	Martin Aasbrenn Mathilde Svendstrup Theresia M Schnurr Dorte Lindqvist Hansen Dorte Worm Marie Balslev-Harder Niels Grarup Kristoffer Sølvsten Burgdorf Henrik Vestergaard Oluf Pedersen Lars Ängquist Mogens Fenger Thorkild I A Sørensen Sten Madsbad Torben Hansen
author_facet	Martin Aasbrenn Mathilde Svendstrup Theresia M Schnurr Dorte Lindqvist Hansen Dorte Worm Marie Balslev-Harder Niels Grarup Kristoffer Sølvsten Burgdorf Henrik Vestergaard Oluf Pedersen Lars Ängquist Mogens Fenger Thorkild I A Sørensen Sten Madsbad Torben Hansen
author_sort	Martin Aasbrenn
title	Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
title_short	Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
title_full	Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
title_fullStr	Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
title_full_unstemmed	Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
title_sort	genetic markers of abdominal obesity and weight loss after gastric bypass surgery.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f964dd36b8994f65a3720e2fb3fd45fd
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Genetic markers of abdominal obesity and weight loss after gastric bypass surgery.

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