A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome
Metabolic syndrome is characterized by complex phenotypes that increases the risk of cardiovascular disease and type 2 diabetes. Here the authors’ integrative network analysis suggests BTK inhibitor ibrutinib to be a promising treatment through its obesity-associated inflammation lowering effect.
Enregistré dans:
Auteurs principaux: | Karla Misselbeck, Silvia Parolo, Francesca Lorenzini, Valeria Savoca, Lorena Leonardelli, Pranami Bora, Melissa J. Morine, Maria Caterina Mione, Enrico Domenici, Corrado Priami |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f96705c65bfd49bc85730e82b064dab7 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis
par: Karla Misselbeck, et autres
Publié: (2017) -
Integrative analysis of pathway deregulation in obesity
par: Francesc Font-Clos, et autres
Publié: (2017) -
Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
par: Felix D. Weiss, et autres
Publié: (2021) -
Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome.
par: Ilario De Toma, et autres
Publié: (2021) -
SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
par: Endre Sebestyén, et autres
Publié: (2020)