Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

ABSTRACT Production of short-chain fatty acids (SCFAs), especially butyrate, in the gut microbiome is required for optimal health but is frequently limited by the lack of fermentable fiber in the diet. We attempted to increase butyrate production by supplementing the diets of 174 healthy young adult...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nielson T. Baxter, Alexander W. Schmidt, Arvind Venkataraman, Kwi S. Kim, Clive Waldron, Thomas M. Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	bifidobacteria butyrate microbiome Ruminococcus SCFA prebiotic Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f969325b136e4a3da44a7187456d67fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f969325b136e4a3da44a7187456d67fe
record_format	dspace
spelling	oai:doaj.org-article:f969325b136e4a3da44a7187456d67fe2021-11-15T15:55:14ZDynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers10.1128/mBio.02566-182150-7511https://doaj.org/article/f969325b136e4a3da44a7187456d67fe2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02566-18https://doaj.org/toc/2150-7511ABSTRACT Production of short-chain fatty acids (SCFAs), especially butyrate, in the gut microbiome is required for optimal health but is frequently limited by the lack of fermentable fiber in the diet. We attempted to increase butyrate production by supplementing the diets of 174 healthy young adults for 2 weeks with resistant starch from potatoes (RPS), resistant starch from maize (RMS), inulin from chicory root, or an accessible corn starch control. RPS resulted in the greatest increase in total SCFAs, including butyrate. Although the majority of microbiomes responded to RPS with increases in the relative abundance of bifidobacteria, those that responded with an increase in Ruminococcus bromii or Clostridium chartatabidum were more likely to yield higher butyrate concentrations, especially when their microbiota were replete with populations of the butyrate-producing species Eubacterium rectale. RMS and inulin induced different changes in fecal communities, but they did not generate significant increases in fecal butyrate levels. IMPORTANCE These results reveal that not all fermentable fibers are equally capable of stimulating SCFA production, and they highlight the importance of the composition of an individual’s microbiota in determining whether or not they respond to a specific dietary supplement. In particular, R. bromii or C. chartatabidum may be required for enhanced butyrate production in response to RS. Bifidobacteria, though proficient at degrading RS and inulin, may not contribute to the butyrogenic effect of those fermentable fibers in the short term.Nielson T. BaxterAlexander W. SchmidtArvind VenkataramanKwi S. KimClive WaldronThomas M. SchmidtAmerican Society for MicrobiologyarticlebifidobacteriabutyratemicrobiomeRuminococcusSCFAprebioticMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bifidobacteria butyrate microbiome Ruminococcus SCFA prebiotic Microbiology QR1-502
spellingShingle	bifidobacteria butyrate microbiome Ruminococcus SCFA prebiotic Microbiology QR1-502 Nielson T. Baxter Alexander W. Schmidt Arvind Venkataraman Kwi S. Kim Clive Waldron Thomas M. Schmidt Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
description	ABSTRACT Production of short-chain fatty acids (SCFAs), especially butyrate, in the gut microbiome is required for optimal health but is frequently limited by the lack of fermentable fiber in the diet. We attempted to increase butyrate production by supplementing the diets of 174 healthy young adults for 2 weeks with resistant starch from potatoes (RPS), resistant starch from maize (RMS), inulin from chicory root, or an accessible corn starch control. RPS resulted in the greatest increase in total SCFAs, including butyrate. Although the majority of microbiomes responded to RPS with increases in the relative abundance of bifidobacteria, those that responded with an increase in Ruminococcus bromii or Clostridium chartatabidum were more likely to yield higher butyrate concentrations, especially when their microbiota were replete with populations of the butyrate-producing species Eubacterium rectale. RMS and inulin induced different changes in fecal communities, but they did not generate significant increases in fecal butyrate levels. IMPORTANCE These results reveal that not all fermentable fibers are equally capable of stimulating SCFA production, and they highlight the importance of the composition of an individual’s microbiota in determining whether or not they respond to a specific dietary supplement. In particular, R. bromii or C. chartatabidum may be required for enhanced butyrate production in response to RS. Bifidobacteria, though proficient at degrading RS and inulin, may not contribute to the butyrogenic effect of those fermentable fibers in the short term.
format	article
author	Nielson T. Baxter Alexander W. Schmidt Arvind Venkataraman Kwi S. Kim Clive Waldron Thomas M. Schmidt
author_facet	Nielson T. Baxter Alexander W. Schmidt Arvind Venkataraman Kwi S. Kim Clive Waldron Thomas M. Schmidt
author_sort	Nielson T. Baxter
title	Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
title_short	Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
title_full	Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
title_fullStr	Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
title_full_unstemmed	Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers
title_sort	dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/f969325b136e4a3da44a7187456d67fe
work_keys_str_mv	AT nielsontbaxter dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers AT alexanderwschmidt dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers AT arvindvenkataraman dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers AT kwiskim dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers AT clivewaldron dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers AT thomasmschmidt dynamicsofhumangutmicrobiotaandshortchainfattyacidsinresponsetodietaryinterventionswiththreefermentablefibers
_version_	1718427253563457536

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

Ejemplares similares