Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation

Abstract Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. S...

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Autores principales:	Mohammad Z. Darabseh, Thomas M. Maden-Wilkinson, George Welbourne, Rob C. I. Wüst, Nessar Ahmed, Hakima Aushah, James Selfe, Christopher I. Morse, Hans Degens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f96ab67045664b7b865aaa69b8d9774e
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spelling	oai:doaj.org-article:f96ab67045664b7b865aaa69b8d9774e2021-12-02T17:30:40ZFourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation10.1038/s41598-021-91510-x2045-2322https://doaj.org/article/f96ab67045664b7b865aaa69b8d9774e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91510-xhttps://doaj.org/toc/2045-2322Abstract Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.Mohammad Z. DarabsehThomas M. Maden-WilkinsonGeorge WelbourneRob C. I. WüstNessar AhmedHakima AushahJames SelfeChristopher I. MorseHans DegensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Z. Darabseh Thomas M. Maden-Wilkinson George Welbourne Rob C. I. Wüst Nessar Ahmed Hakima Aushah James Selfe Christopher I. Morse Hans Degens Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
description	Abstract Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.
format	article
author	Mohammad Z. Darabseh Thomas M. Maden-Wilkinson George Welbourne Rob C. I. Wüst Nessar Ahmed Hakima Aushah James Selfe Christopher I. Morse Hans Degens
author_facet	Mohammad Z. Darabseh Thomas M. Maden-Wilkinson George Welbourne Rob C. I. Wüst Nessar Ahmed Hakima Aushah James Selfe Christopher I. Morse Hans Degens
author_sort	Mohammad Z. Darabseh
title	Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_short	Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_full	Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_fullStr	Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_full_unstemmed	Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_sort	fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f96ab67045664b7b865aaa69b8d9774e
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Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation

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