Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance

Abstract The diversity in plant metabolites with improved phytonutrients is essential to achieve global food security and sustainable crop yield. Our study using computational metabolomics genome wide association study (cmGWAS) reports on a comprehensive profiling of threonine (Thr) metabolite in ri...

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Autores principales:	Pandiyan Muthuramalingam, Subramanian Radhesh Krishnan, Subramani Pandian, Narayanan Mareeswaran, Wilson Aruni, Shunmugiah Karutha Pandian, Manikandan Ramesh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f96c893aae4f494399166b3d382a9b94
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spelling	oai:doaj.org-article:f96c893aae4f494399166b3d382a9b942021-12-02T15:09:10ZGlobal analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance10.1038/s41598-018-27703-82045-2322https://doaj.org/article/f96c893aae4f494399166b3d382a9b942018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27703-8https://doaj.org/toc/2045-2322Abstract The diversity in plant metabolites with improved phytonutrients is essential to achieve global food security and sustainable crop yield. Our study using computational metabolomics genome wide association study (cmGWAS) reports on a comprehensive profiling of threonine (Thr) metabolite in rice. Sixteen abiotic stress responsive (AbSR) – Thr metabolite producing genes (ThrMPG), modulate metabolite levels and play a significant role determining both physiological and nutritional importance of rice. These AbSR-ThrMPG were computationally analysed for their protein properties using OryzaCyc through plant metabolic network analyser. A total of 1373 and 1028 SNPs were involved in complex traits and genomic variations. Comparative mapping of AbSR-ThrMPG revealed the chromosomal colinearity with C4 grass species. Further, computational expression pattern of these genes predicted a differential expression profiling in diverse developmental tissues. Protein interaction of protein coding gene sequences revealed that the abiotic stresses (AbS) are multigenic in nature. In silico expression of AbSR-ThrMPG determined the putative involvement in response to individual AbS. This is the first comprehensive genome wide study reporting on AbSR –ThrMPG analysis in rice. The results of this study provide a pivotal resource for further functional investigation of these key genes in the vital areas of manipulating AbS signaling in rice improvement.Pandiyan MuthuramalingamSubramanian Radhesh KrishnanSubramani PandianNarayanan MareeswaranWilson AruniShunmugiah Karutha PandianManikandan RameshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pandiyan Muthuramalingam Subramanian Radhesh Krishnan Subramani Pandian Narayanan Mareeswaran Wilson Aruni Shunmugiah Karutha Pandian Manikandan Ramesh Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
description	Abstract The diversity in plant metabolites with improved phytonutrients is essential to achieve global food security and sustainable crop yield. Our study using computational metabolomics genome wide association study (cmGWAS) reports on a comprehensive profiling of threonine (Thr) metabolite in rice. Sixteen abiotic stress responsive (AbSR) – Thr metabolite producing genes (ThrMPG), modulate metabolite levels and play a significant role determining both physiological and nutritional importance of rice. These AbSR-ThrMPG were computationally analysed for their protein properties using OryzaCyc through plant metabolic network analyser. A total of 1373 and 1028 SNPs were involved in complex traits and genomic variations. Comparative mapping of AbSR-ThrMPG revealed the chromosomal colinearity with C4 grass species. Further, computational expression pattern of these genes predicted a differential expression profiling in diverse developmental tissues. Protein interaction of protein coding gene sequences revealed that the abiotic stresses (AbS) are multigenic in nature. In silico expression of AbSR-ThrMPG determined the putative involvement in response to individual AbS. This is the first comprehensive genome wide study reporting on AbSR –ThrMPG analysis in rice. The results of this study provide a pivotal resource for further functional investigation of these key genes in the vital areas of manipulating AbS signaling in rice improvement.
format	article
author	Pandiyan Muthuramalingam Subramanian Radhesh Krishnan Subramani Pandian Narayanan Mareeswaran Wilson Aruni Shunmugiah Karutha Pandian Manikandan Ramesh
author_facet	Pandiyan Muthuramalingam Subramanian Radhesh Krishnan Subramani Pandian Narayanan Mareeswaran Wilson Aruni Shunmugiah Karutha Pandian Manikandan Ramesh
author_sort	Pandiyan Muthuramalingam
title	Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
title_short	Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
title_full	Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
title_fullStr	Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
title_full_unstemmed	Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
title_sort	global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f96c893aae4f494399166b3d382a9b94
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Global analysis of threonine metabolism genes unravel key players in rice to improve the abiotic stress tolerance

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