Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition
Ki-Hong Hong,1 Young Lee2 1Department of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, Seoul 05368, Republic of Korea; 2Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of KoreaCorrespondence: Ki-Hong HongDepartment of Family Medicine,...
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2020
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oai:doaj.org-article:f97113dcd83347098750e147e8d984772021-12-02T12:14:35ZNegative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition1178-7031https://doaj.org/article/f97113dcd83347098750e147e8d984772020-10-01T00:00:00Zhttps://www.dovepress.com/negative-correlation-between-vitamin-a-and-positive-correlation-betwee-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Ki-Hong Hong,1 Young Lee2 1Department of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, Seoul 05368, Republic of Korea; 2Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of KoreaCorrespondence: Ki-Hong HongDepartment of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, 53, Jinhwangdo-Ro 61-Gil, Gangdong-Gu, Seoul 05368, Republic of KoreaTel +82-2-2225-4325Fax +82-2-2225-1178Email hkhtech@naver.comPurpose: Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, α-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES).Materials and Methods: This study was based on data acquired from the 7th edition (2016– 2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum α-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics.Results: There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched.Conclusion: There was a negative correlation between serum retinol and hs-CRP and positive correlation between α-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.Keywords: metabolic syndrome, retinol, α-tocopherol, smoking, drinkingHong KHLee YDove Medical Pressarticlemetabolic syndromeretinolα-tocopherolsmokingdrinkingPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 799-811 (2020) |
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metabolic syndrome retinol α-tocopherol smoking drinking Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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metabolic syndrome retinol α-tocopherol smoking drinking Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Hong KH Lee Y Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| description |
Ki-Hong Hong,1 Young Lee2 1Department of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, Seoul 05368, Republic of Korea; 2Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of KoreaCorrespondence: Ki-Hong HongDepartment of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, 53, Jinhwangdo-Ro 61-Gil, Gangdong-Gu, Seoul 05368, Republic of KoreaTel +82-2-2225-4325Fax +82-2-2225-1178Email hkhtech@naver.comPurpose: Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, α-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES).Materials and Methods: This study was based on data acquired from the 7th edition (2016– 2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum α-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics.Results: There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched.Conclusion: There was a negative correlation between serum retinol and hs-CRP and positive correlation between α-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.Keywords: metabolic syndrome, retinol, α-tocopherol, smoking, drinking |
| format |
article |
| author |
Hong KH Lee Y |
| author_facet |
Hong KH Lee Y |
| author_sort |
Hong KH |
| title |
Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| title_short |
Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| title_full |
Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| title_fullStr |
Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| title_full_unstemmed |
Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition |
| title_sort |
negative correlation between vitamin a and positive correlation between vitamin e and inflammation among healthy adults in korea: based on the korea national health and nutrition examination survey (knhanes) 2016–2018 7th edition |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/f97113dcd83347098750e147e8d98477 |
| work_keys_str_mv |
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| _version_ |
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