Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Maryam N. Shahin, Stephen G. Bowden, Nasser K. Yaghi, Jacob H. Bagley, Seunggu J. Han, Elena V. Varlamov, Marjorie R. Grafe, Justin S. Cetas
Formato: article
Lenguaje:EN
Publicado: Georg Thieme Verlag KG 2021
Materias:
Acceso en línea:https://doaj.org/article/f971b25d5c1b48029accc53d40fdb819
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.