Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility...

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Autores principales:	Maryam N. Shahin, Stephen G. Bowden, Nasser K. Yaghi, Jacob H. Bagley, Seunggu J. Han, Elena V. Varlamov, Marjorie R. Grafe, Justin S. Cetas
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	meningioma estrogen progesterone endometriosis Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f971b25d5c1b48029accc53d40fdb819
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spelling	oai:doaj.org-article:f971b25d5c1b48029accc53d40fdb8192021-12-01T23:46:39ZRegression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report2193-63582193-636610.1055/s-0041-1735553https://doaj.org/article/f971b25d5c1b48029accc53d40fdb8192021-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735553https://doaj.org/toc/2193-6358https://doaj.org/toc/2193-6366Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.Maryam N. ShahinStephen G. BowdenNasser K. YaghiJacob H. BagleySeunggu J. HanElena V. VarlamovMarjorie R. GrafeJustin S. CetasGeorg Thieme Verlag KGarticlemeningiomaestrogenprogesteroneendometriosisSurgeryRD1-811Neurology. Diseases of the nervous systemRC346-429ENJournal of Neurological Surgery Reports, Vol 82, Iss 04, Pp e38-e42 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	meningioma estrogen progesterone endometriosis Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429
spellingShingle	meningioma estrogen progesterone endometriosis Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429 Maryam N. Shahin Stephen G. Bowden Nasser K. Yaghi Jacob H. Bagley Seunggu J. Han Elena V. Varlamov Marjorie R. Grafe Justin S. Cetas Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
description	Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.
format	article
author	Maryam N. Shahin Stephen G. Bowden Nasser K. Yaghi Jacob H. Bagley Seunggu J. Han Elena V. Varlamov Marjorie R. Grafe Justin S. Cetas
author_facet	Maryam N. Shahin Stephen G. Bowden Nasser K. Yaghi Jacob H. Bagley Seunggu J. Han Elena V. Varlamov Marjorie R. Grafe Justin S. Cetas
author_sort	Maryam N. Shahin
title	Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
title_short	Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
title_full	Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
title_fullStr	Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
title_full_unstemmed	Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report
title_sort	regression of multiple meningiomas after discontinuation of chronic hormone therapy: a case report
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/f971b25d5c1b48029accc53d40fdb819
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Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

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