A Case of Severe COVID-19 in a Patient with Good's Syndrome

Good’s syndrome is a rare adult-onset combined immunodeficiency. The association of hypogammaglobulinaemia with a history of recurrent infectious or autoimmune manifestations in a middle-aged patient with evidence of a mediastinal mass should lead to the clinical suspicion of Good’s syndrome. The mo...

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Autores principales:	Maria Duarte, Luciana Faria, Catarina Patronillo, Sónia da Costa Fernandes, Vera Seara
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	covid-19 good’s syndrome immunoglobulin Medicine R
Acceso en línea:	https://doaj.org/article/f9728687965a4eb1bdd14e75671f241f
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spelling	oai:doaj.org-article:f9728687965a4eb1bdd14e75671f241f2021-11-09T11:21:26ZA Case of Severe COVID-19 in a Patient with Good's Syndrome2284-259410.12890/2021_002976https://doaj.org/article/f9728687965a4eb1bdd14e75671f241f2021-10-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2976https://doaj.org/toc/2284-2594Good’s syndrome is a rare adult-onset combined immunodeficiency. The association of hypogammaglobulinaemia with a history of recurrent infectious or autoimmune manifestations in a middle-aged patient with evidence of a mediastinal mass should lead to the clinical suspicion of Good’s syndrome. The mortality rate associated with infectious complications is high. Thus, although it is rare, the disease should be diagnosed early so that proper treatment can be started. Thymectomy and immunoglobulin replacement are the main therapeutic strategies. We describe the case of a patient with a history of thymoma and recurrent respiratory infections, with a late diagnosis of Good’s syndrome in the context of severe organizing pneumonia secondary to COVID-19.Maria DuarteLuciana FariaCatarina PatronilloSónia da Costa FernandesVera SearaSMC MEDIA SRLarticlecovid-19good’s syndromeimmunoglobulinMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 good’s syndrome immunoglobulin Medicine R
spellingShingle	covid-19 good’s syndrome immunoglobulin Medicine R Maria Duarte Luciana Faria Catarina Patronillo Sónia da Costa Fernandes Vera Seara A Case of Severe COVID-19 in a Patient with Good's Syndrome
description	Good’s syndrome is a rare adult-onset combined immunodeficiency. The association of hypogammaglobulinaemia with a history of recurrent infectious or autoimmune manifestations in a middle-aged patient with evidence of a mediastinal mass should lead to the clinical suspicion of Good’s syndrome. The mortality rate associated with infectious complications is high. Thus, although it is rare, the disease should be diagnosed early so that proper treatment can be started. Thymectomy and immunoglobulin replacement are the main therapeutic strategies. We describe the case of a patient with a history of thymoma and recurrent respiratory infections, with a late diagnosis of Good’s syndrome in the context of severe organizing pneumonia secondary to COVID-19.
format	article
author	Maria Duarte Luciana Faria Catarina Patronillo Sónia da Costa Fernandes Vera Seara
author_facet	Maria Duarte Luciana Faria Catarina Patronillo Sónia da Costa Fernandes Vera Seara
author_sort	Maria Duarte
title	A Case of Severe COVID-19 in a Patient with Good's Syndrome
title_short	A Case of Severe COVID-19 in a Patient with Good's Syndrome
title_full	A Case of Severe COVID-19 in a Patient with Good's Syndrome
title_fullStr	A Case of Severe COVID-19 in a Patient with Good's Syndrome
title_full_unstemmed	A Case of Severe COVID-19 in a Patient with Good's Syndrome
title_sort	case of severe covid-19 in a patient with good's syndrome
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/f9728687965a4eb1bdd14e75671f241f
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A Case of Severe COVID-19 in a Patient with Good's Syndrome

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