Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer

Background: The primary endpoint was to analyze the preoperatory inflammatory markers and platelet indices in papillary thyroid cancer (PTC) patients compared with patients with benign thyroid pathology. The secondary endpoints were to analyze the relationship between these markers and the pathologi...

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Autores principales:	Sorina Martin, Theodor Mustata, Oana Enache, Oana Ion, Andreea Chifulescu, Anca Sirbu, Carmen Barbu, Adrian Miron, Cosmin Giulea, Florin Andrei, Simona Fica
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	differentiated thyroid cancer papillary thyroid cancer inflammatory markers platelet indices Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9764d58c17b4456923278c66e2420b3
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spelling	oai:doaj.org-article:f9764d58c17b4456923278c66e2420b32021-11-25T17:20:14ZPlatelet Activation and Inflammation in Patients with Papillary Thyroid Cancer10.3390/diagnostics111119592075-4418https://doaj.org/article/f9764d58c17b4456923278c66e2420b32021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1959https://doaj.org/toc/2075-4418Background: The primary endpoint was to analyze the preoperatory inflammatory markers and platelet indices in papillary thyroid cancer (PTC) patients compared with patients with benign thyroid pathology. The secondary endpoints were to analyze the relationship between these markers and the pathological features of PTC and to compare their pre- and postoperative levels in PTC patients. Methods: In this retrospective case-control study, we analyzed the files of 1183 patients submitted to thyroidectomy between January 2012 and December 2018. A total of 234 patients with PTC (mean age 51.54 ± 13.10 years, 84.6% females) were compared with an age-, gender- and BMI-matched control group of 108 patients with histologic benign thyroid disorders. Results: PTC patients had higher platelet count (PLT) (<i>p</i> = 0.011), plateletcrit (PCT) (<i>p</i> = 0.006), neutrophil (<i>p</i> = 0.022) and fibrinogen (<i>p</i> = 0.005) levels. Subgroup analysis showed that PTC females had higher PLT (<i>p</i> = 0.006), PCT (<i>p</i> < 0.001) and erythrocyte sedimentation rate (ESR) (<i>p</i> = 0.005), while males had higher neutrophil (<i>p</i> = 0.040) levels. Papillary thyroid cancer patients under 55 years had higher PLT (<i>p</i> < 0.001) and PCT (<i>p</i> = 0.010), while patients over 55 years had higher mean platelet volume (<i>p</i> = 0.032), neutrophil-to-lymphocyte ratio (<i>p</i> = 0.013), ESR (<i>p</i> = 0.005) and fibrinogen (<i>p</i> = 0.019) levels. Preoperative values for platelet indices and inflammatory markers were similar to the postoperative determinations in PTC patients. Fibrinogen (AUROC = 0.602, <i>p</i> = 0.02; cut-off = 327.5 mg/dL, Se = 53.8%, Sp = 62.9%) and PLT (AUROC = 0.584, <i>p</i> = 0.012; cut-off = 223.5 × 10<sup>3</sup>/mm<sup>3</sup>, Se = 73.1%, Sp = 42.6%) were independent predictors of the presence of PTC. Conclusions: Our data show that fibrinogen and platelet count could be promising, inexpensive, independent predictors for the presence of PTC when compared with benign thyroid disorders.Sorina MartinTheodor MustataOana EnacheOana IonAndreea ChifulescuAnca SirbuCarmen BarbuAdrian MironCosmin GiuleaFlorin AndreiSimona FicaMDPI AGarticledifferentiated thyroid cancerpapillary thyroid cancerinflammatory markersplatelet indicesMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1959, p 1959 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	differentiated thyroid cancer papillary thyroid cancer inflammatory markers platelet indices Medicine (General) R5-920
spellingShingle	differentiated thyroid cancer papillary thyroid cancer inflammatory markers platelet indices Medicine (General) R5-920 Sorina Martin Theodor Mustata Oana Enache Oana Ion Andreea Chifulescu Anca Sirbu Carmen Barbu Adrian Miron Cosmin Giulea Florin Andrei Simona Fica Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
description	Background: The primary endpoint was to analyze the preoperatory inflammatory markers and platelet indices in papillary thyroid cancer (PTC) patients compared with patients with benign thyroid pathology. The secondary endpoints were to analyze the relationship between these markers and the pathological features of PTC and to compare their pre- and postoperative levels in PTC patients. Methods: In this retrospective case-control study, we analyzed the files of 1183 patients submitted to thyroidectomy between January 2012 and December 2018. A total of 234 patients with PTC (mean age 51.54 ± 13.10 years, 84.6% females) were compared with an age-, gender- and BMI-matched control group of 108 patients with histologic benign thyroid disorders. Results: PTC patients had higher platelet count (PLT) (<i>p</i> = 0.011), plateletcrit (PCT) (<i>p</i> = 0.006), neutrophil (<i>p</i> = 0.022) and fibrinogen (<i>p</i> = 0.005) levels. Subgroup analysis showed that PTC females had higher PLT (<i>p</i> = 0.006), PCT (<i>p</i> < 0.001) and erythrocyte sedimentation rate (ESR) (<i>p</i> = 0.005), while males had higher neutrophil (<i>p</i> = 0.040) levels. Papillary thyroid cancer patients under 55 years had higher PLT (<i>p</i> < 0.001) and PCT (<i>p</i> = 0.010), while patients over 55 years had higher mean platelet volume (<i>p</i> = 0.032), neutrophil-to-lymphocyte ratio (<i>p</i> = 0.013), ESR (<i>p</i> = 0.005) and fibrinogen (<i>p</i> = 0.019) levels. Preoperative values for platelet indices and inflammatory markers were similar to the postoperative determinations in PTC patients. Fibrinogen (AUROC = 0.602, <i>p</i> = 0.02; cut-off = 327.5 mg/dL, Se = 53.8%, Sp = 62.9%) and PLT (AUROC = 0.584, <i>p</i> = 0.012; cut-off = 223.5 × 10<sup>3</sup>/mm<sup>3</sup>, Se = 73.1%, Sp = 42.6%) were independent predictors of the presence of PTC. Conclusions: Our data show that fibrinogen and platelet count could be promising, inexpensive, independent predictors for the presence of PTC when compared with benign thyroid disorders.
format	article
author	Sorina Martin Theodor Mustata Oana Enache Oana Ion Andreea Chifulescu Anca Sirbu Carmen Barbu Adrian Miron Cosmin Giulea Florin Andrei Simona Fica
author_facet	Sorina Martin Theodor Mustata Oana Enache Oana Ion Andreea Chifulescu Anca Sirbu Carmen Barbu Adrian Miron Cosmin Giulea Florin Andrei Simona Fica
author_sort	Sorina Martin
title	Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
title_short	Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
title_full	Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
title_fullStr	Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
title_full_unstemmed	Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
title_sort	platelet activation and inflammation in patients with papillary thyroid cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f9764d58c17b4456923278c66e2420b3
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Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer

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