Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

Abstract Sepsis, during which the intestinal epithelial barrier is frequently disrupted, remains a challenging and life-threatening problem in clinical practice. The P2X7 receptor (P2X7R) is a non-selective adenosine triphosphate-gated cation channel present in macrophages that is involved in inflam...

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Autores principales: Xiuwen Wu, Jianan Ren, Guopu Chen, Lei Wu, Xian Song, Guanwei Li, Youming Deng, Gefei Wang, Guosheng Gu, Jieshou Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/f977ba3be8c943cc8d7dc7deee0d72ec
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