Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic expression and the distal enhancer enforcing...

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Autores principales:	Wooseok Seo, Kanako Shimizu, Satoshi Kojo, Arinze Okeke, Terumi Kohwi-Shigematsu, Shin-ichiro Fujii, Ichiro Taniuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f978d8867e1c4bb0aad0b3d7ee5a4256
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spelling	oai:doaj.org-article:f978d8867e1c4bb0aad0b3d7ee5a42562021-12-02T16:49:30ZRunx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity10.1038/s41467-020-15375-w2041-1723https://doaj.org/article/f978d8867e1c4bb0aad0b3d7ee5a42562020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15375-whttps://doaj.org/toc/2041-1723CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic expression and the distal enhancer enforcing inducibility, while both enhancers are modulated by RUNX3.Wooseok SeoKanako ShimizuSatoshi KojoArinze OkekeTerumi Kohwi-ShigematsuShin-ichiro FujiiIchiro TaniuchiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wooseok Seo Kanako Shimizu Satoshi Kojo Arinze Okeke Terumi Kohwi-Shigematsu Shin-ichiro Fujii Ichiro Taniuchi Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
description	CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic expression and the distal enhancer enforcing inducibility, while both enhancers are modulated by RUNX3.
format	article
author	Wooseok Seo Kanako Shimizu Satoshi Kojo Arinze Okeke Terumi Kohwi-Shigematsu Shin-ichiro Fujii Ichiro Taniuchi
author_facet	Wooseok Seo Kanako Shimizu Satoshi Kojo Arinze Okeke Terumi Kohwi-Shigematsu Shin-ichiro Fujii Ichiro Taniuchi
author_sort	Wooseok Seo
title	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
title_short	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
title_full	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
title_fullStr	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
title_full_unstemmed	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
title_sort	runx-mediated regulation of ccl5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f978d8867e1c4bb0aad0b3d7ee5a4256
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Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

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