Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic expression and the distal enhancer enforcing...

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Autores principales: Wooseok Seo, Kanako Shimizu, Satoshi Kojo, Arinze Okeke, Terumi Kohwi-Shigematsu, Shin-ichiro Fujii, Ichiro Taniuchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/f978d8867e1c4bb0aad0b3d7ee5a4256
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