UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression delays motor neuron degeneration in a Xenopus model.

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Autores principales:	Min Ji Yoon, Boyoon Choi, Eun Jin Kim, Jiyeon Ohk, Chansik Yang, Yeon-Gil Choi, Jinyoung Lee, Chanhee Kang, Hyun Kyu Song, Yoon Ki Kim, Jae-Sung Woo, Yongcheol Cho, Eui-Ju Choi, Hosung Jung, Chungho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f97d34af557c40b1a93c7c19606cff1c
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spelling	oai:doaj.org-article:f97d34af557c40b1a93c7c19606cff1c2021-12-02T14:25:31ZUXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy10.1038/s41467-021-22252-72041-1723https://doaj.org/article/f97d34af557c40b1a93c7c19606cff1c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22252-7https://doaj.org/toc/2041-1723p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression delays motor neuron degeneration in a Xenopus model.Min Ji YoonBoyoon ChoiEun Jin KimJiyeon OhkChansik YangYeon-Gil ChoiJinyoung LeeChanhee KangHyun Kyu SongYoon Ki KimJae-Sung WooYongcheol ChoEui-Ju ChoiHosung JungChungho KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Ji Yoon Boyoon Choi Eun Jin Kim Jiyeon Ohk Chansik Yang Yeon-Gil Choi Jinyoung Lee Chanhee Kang Hyun Kyu Song Yoon Ki Kim Jae-Sung Woo Yongcheol Cho Eui-Ju Choi Hosung Jung Chungho Kim UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
description	p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression delays motor neuron degeneration in a Xenopus model.
format	article
author	Min Ji Yoon Boyoon Choi Eun Jin Kim Jiyeon Ohk Chansik Yang Yeon-Gil Choi Jinyoung Lee Chanhee Kang Hyun Kyu Song Yoon Ki Kim Jae-Sung Woo Yongcheol Cho Eui-Ju Choi Hosung Jung Chungho Kim
author_facet	Min Ji Yoon Boyoon Choi Eun Jin Kim Jiyeon Ohk Chansik Yang Yeon-Gil Choi Jinyoung Lee Chanhee Kang Hyun Kyu Song Yoon Ki Kim Jae-Sung Woo Yongcheol Cho Eui-Ju Choi Hosung Jung Chungho Kim
author_sort	Min Ji Yoon
title	UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
title_short	UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
title_full	UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
title_fullStr	UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
title_full_unstemmed	UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
title_sort	uxt chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f97d34af557c40b1a93c7c19606cff1c
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UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

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