How do our cells build their protein interactome?

Abstract Chaperones are cellular factors that help in the folding of newly synthesized polypeptides (or clients) and, in some cases, ensure their integration within larger complexes. They often require non-client proteins, or co-chaperones, to help drive specificity to particular target polypeptides...

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Autores principales:	Benoit Coulombe, Philippe Cloutier, Marie-Soleil Gauthier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f97f4fd0ce644bb78fe9541ee2c93901
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spelling	oai:doaj.org-article:f97f4fd0ce644bb78fe9541ee2c939012021-12-02T15:34:49ZHow do our cells build their protein interactome?10.1038/s41467-018-05448-22041-1723https://doaj.org/article/f97f4fd0ce644bb78fe9541ee2c939012018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05448-2https://doaj.org/toc/2041-1723Abstract Chaperones are cellular factors that help in the folding of newly synthesized polypeptides (or clients) and, in some cases, ensure their integration within larger complexes. They often require non-client proteins, or co-chaperones, to help drive specificity to particular target polypeptides or facilitate the nucleotide hydrolysis cycle of some chaperones. The latest findings on the characterization of the PAQosome (Particle for Arrangement of Quaternary structure; formerly known as R2TP/PFDL complex) published recently in Nature Communications help to explain how this particular co-chaperone plays a central role in organizing our proteome into protein complexes and networks. The exploitation by the cell of alternative PAQosomes formed through the differential integration of homologous subunits, in conjunction with the use of several adaptors (specificity factors), provide the conceptual basis for interaction of multiple clients in a structure that is favorable to their simultaneous binding en route to protein complex and network assembly/maturation.Benoit CoulombePhilippe CloutierMarie-Soleil GauthierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benoit Coulombe Philippe Cloutier Marie-Soleil Gauthier How do our cells build their protein interactome?
description	Abstract Chaperones are cellular factors that help in the folding of newly synthesized polypeptides (or clients) and, in some cases, ensure their integration within larger complexes. They often require non-client proteins, or co-chaperones, to help drive specificity to particular target polypeptides or facilitate the nucleotide hydrolysis cycle of some chaperones. The latest findings on the characterization of the PAQosome (Particle for Arrangement of Quaternary structure; formerly known as R2TP/PFDL complex) published recently in Nature Communications help to explain how this particular co-chaperone plays a central role in organizing our proteome into protein complexes and networks. The exploitation by the cell of alternative PAQosomes formed through the differential integration of homologous subunits, in conjunction with the use of several adaptors (specificity factors), provide the conceptual basis for interaction of multiple clients in a structure that is favorable to their simultaneous binding en route to protein complex and network assembly/maturation.
format	article
author	Benoit Coulombe Philippe Cloutier Marie-Soleil Gauthier
author_facet	Benoit Coulombe Philippe Cloutier Marie-Soleil Gauthier
author_sort	Benoit Coulombe
title	How do our cells build their protein interactome?
title_short	How do our cells build their protein interactome?
title_full	How do our cells build their protein interactome?
title_fullStr	How do our cells build their protein interactome?
title_full_unstemmed	How do our cells build their protein interactome?
title_sort	how do our cells build their protein interactome?
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f97f4fd0ce644bb78fe9541ee2c93901
work_keys_str_mv	AT benoitcoulombe howdoourcellsbuildtheirproteininteractome AT philippecloutier howdoourcellsbuildtheirproteininteractome AT mariesoleilgauthier howdoourcellsbuildtheirproteininteractome
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How do our cells build their protein interactome?

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