Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer

Jingfeng Wang,1,2,&ast; Jian Liu,3,&ast; Longfei Gao,3 Guangqiao Li,1,2 Yilin Sun,3 Bo Shi1,2 1School of Medical Imaging, Bengbu Medical College, Bengbu, Anhui, 233030, People’s Republic of China; 2Anhui Key Laboratory of Computational Medicine and Intelligent Health, Bengbu Medical College,...

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Autores principales:	Wang J, Liu J, Gao L, Li G, Sun Y, Shi B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cervical cancer heart rate variability lymph node metastasis autonomic nervous system Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f980c79cce0b4059bed42950a67873af
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spelling	oai:doaj.org-article:f980c79cce0b4059bed42950a67873af2021-11-23T18:43:01ZHeart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer1179-1322https://doaj.org/article/f980c79cce0b4059bed42950a67873af2021-11-01T00:00:00Zhttps://www.dovepress.com/heart-rate-variability-is-an-independent-predictor-of-lymph-node-metas-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Jingfeng Wang,1,2,&ast; Jian Liu,3,&ast; Longfei Gao,3 Guangqiao Li,1,2 Yilin Sun,3 Bo Shi1,2 1School of Medical Imaging, Bengbu Medical College, Bengbu, Anhui, 233030, People’s Republic of China; 2Anhui Key Laboratory of Computational Medicine and Intelligent Health, Bengbu Medical College, Bengbu, Anhui, 233030, People’s Republic of China; 3Department of Gynecologic Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui, 233004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bo ShiSchool of Medical Imaging, Bengbu Medical College, Bengbu, Anhui, People’s Republic of ChinaTel +86-18955203003Email shibo@bbmc.edu.cnPurpose: Heart rate variability (HRV) has been reported as a useful biomarker for prognostic factors in a variety of cancers. The purpose of this study was to explore the predictive value of preoperative HRV for lymph node metastasis (LNM) in patients with cervical cancer (CC).Patients and Methods: A total of 77 patients with CC were included, including 18 LNM and 59 non-LNM patients. A five-minute resting electrocardiogram (ECG) was collected before surgery for the analysis of HRV time domain, frequency domain and Poincaré plot parameters (ie, SDNN, RMSSD, LF, HF, LF/HF, SD1, SD2 and SD2/SD1). Student’s t-tests and logistic regression were performed to determine the relationship between HRV and LNM.Results: The LNM group had significantly lower SDNN, LF, and SD2 than the non-LNM group (all p < 0.05; all Cohen’s d > 0.5). Binary logistic regression analysis indicated that SDNN, LF and SD2 were still significantly associated with LNM. Specifically, for each 1 ms decrease in SDNN and SD2 and each 1 logarithmic unit decrease in ln (LF), the odds of LNM increased by 12%, 9%, and 86%, respectively (all p < 0.05).Conclusion: These findings suggest an association between HRV and CC LNM, and HRV could be a potential noninvasive biomarker for the prediction of LNM in CC patients.Keywords: cervical cancer, heart rate variability, lymph node metastasis, autonomic nervous systemWang JLiu JGao LLi GSun YShi BDove Medical Pressarticlecervical cancerheart rate variabilitylymph node metastasisautonomic nervous systemNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8821-8830 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer heart rate variability lymph node metastasis autonomic nervous system Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cervical cancer heart rate variability lymph node metastasis autonomic nervous system Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wang J Liu J Gao L Li G Sun Y Shi B Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
description	Jingfeng Wang,1,2,&ast; Jian Liu,3,&ast; Longfei Gao,3 Guangqiao Li,1,2 Yilin Sun,3 Bo Shi1,2 1School of Medical Imaging, Bengbu Medical College, Bengbu, Anhui, 233030, People’s Republic of China; 2Anhui Key Laboratory of Computational Medicine and Intelligent Health, Bengbu Medical College, Bengbu, Anhui, 233030, People’s Republic of China; 3Department of Gynecologic Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui, 233004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bo ShiSchool of Medical Imaging, Bengbu Medical College, Bengbu, Anhui, People’s Republic of ChinaTel +86-18955203003Email shibo@bbmc.edu.cnPurpose: Heart rate variability (HRV) has been reported as a useful biomarker for prognostic factors in a variety of cancers. The purpose of this study was to explore the predictive value of preoperative HRV for lymph node metastasis (LNM) in patients with cervical cancer (CC).Patients and Methods: A total of 77 patients with CC were included, including 18 LNM and 59 non-LNM patients. A five-minute resting electrocardiogram (ECG) was collected before surgery for the analysis of HRV time domain, frequency domain and Poincaré plot parameters (ie, SDNN, RMSSD, LF, HF, LF/HF, SD1, SD2 and SD2/SD1). Student’s t-tests and logistic regression were performed to determine the relationship between HRV and LNM.Results: The LNM group had significantly lower SDNN, LF, and SD2 than the non-LNM group (all p < 0.05; all Cohen’s d > 0.5). Binary logistic regression analysis indicated that SDNN, LF and SD2 were still significantly associated with LNM. Specifically, for each 1 ms decrease in SDNN and SD2 and each 1 logarithmic unit decrease in ln (LF), the odds of LNM increased by 12%, 9%, and 86%, respectively (all p < 0.05).Conclusion: These findings suggest an association between HRV and CC LNM, and HRV could be a potential noninvasive biomarker for the prediction of LNM in CC patients.Keywords: cervical cancer, heart rate variability, lymph node metastasis, autonomic nervous system
format	article
author	Wang J Liu J Gao L Li G Sun Y Shi B
author_facet	Wang J Liu J Gao L Li G Sun Y Shi B
author_sort	Wang J
title	Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
title_short	Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
title_full	Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
title_fullStr	Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
title_full_unstemmed	Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer
title_sort	heart rate variability is an independent predictor of lymph node metastasis in patients with cervical cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f980c79cce0b4059bed42950a67873af
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Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer

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