Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kauret al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire c...

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Autores principales:	H. Kaur, J. Carvalho, M. Looso, P. Singh, R. Chennupati, J. Preussner, S. Günther, J. Albarrán-Juárez, D. Tischner, S. Classen, S. Offermanns, N. Wettschureck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f981203d8bca4713b9bf08c5fe80d21d
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spelling	oai:doaj.org-article:f981203d8bca4713b9bf08c5fe80d21d2021-12-02T14:42:34ZSingle-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system10.1038/ncomms157002041-1723https://doaj.org/article/f981203d8bca4713b9bf08c5fe80d21d2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15700https://doaj.org/toc/2041-1723GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kauret al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire changes depending on cell type and vascular localization.H. KaurJ. CarvalhoM. LoosoP. SinghR. ChennupatiJ. PreussnerS. GüntherJ. Albarrán-JuárezD. TischnerS. ClassenS. OffermannsN. WettschureckNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q H. Kaur J. Carvalho M. Looso P. Singh R. Chennupati J. Preussner S. Günther J. Albarrán-Juárez D. Tischner S. Classen S. Offermanns N. Wettschureck Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
description	GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kauret al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire changes depending on cell type and vascular localization.
format	article
author	H. Kaur J. Carvalho M. Looso P. Singh R. Chennupati J. Preussner S. Günther J. Albarrán-Juárez D. Tischner S. Classen S. Offermanns N. Wettschureck
author_facet	H. Kaur J. Carvalho M. Looso P. Singh R. Chennupati J. Preussner S. Günther J. Albarrán-Juárez D. Tischner S. Classen S. Offermanns N. Wettschureck
author_sort	H. Kaur
title	Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
title_short	Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
title_full	Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
title_fullStr	Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
title_full_unstemmed	Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
title_sort	single-cell profiling reveals heterogeneity and functional patterning of gpcr expression in the vascular system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f981203d8bca4713b9bf08c5fe80d21d
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Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

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