Genome editing abrogates angiogenesis in vivo

Abnormal angiogenesis causes many ocular diseases. Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascula...

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Autores principales:	Xionggao Huang, Guohong Zhou, Wenyi Wu, Yajian Duan, Gaoen Ma, Jingyuan Song, Ru Xiao, Luk Vandenberghe, Feng Zhang, Patricia A. D’Amore, Hetian Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f981fc904c1b403e9521fe12e9013ee3
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spelling	oai:doaj.org-article:f981fc904c1b403e9521fe12e9013ee32021-12-02T13:57:32ZGenome editing abrogates angiogenesis in vivo10.1038/s41467-017-00140-32041-1723https://doaj.org/article/f981fc904c1b403e9521fe12e9013ee32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00140-3https://doaj.org/toc/2041-1723Abnormal angiogenesis causes many ocular diseases. Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.Xionggao HuangGuohong ZhouWenyi WuYajian DuanGaoen MaJingyuan SongRu XiaoLuk VandenbergheFeng ZhangPatricia A. D’AmoreHetian LeiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xionggao Huang Guohong Zhou Wenyi Wu Yajian Duan Gaoen Ma Jingyuan Song Ru Xiao Luk Vandenberghe Feng Zhang Patricia A. D’Amore Hetian Lei Genome editing abrogates angiogenesis in vivo
description	Abnormal angiogenesis causes many ocular diseases. Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.
format	article
author	Xionggao Huang Guohong Zhou Wenyi Wu Yajian Duan Gaoen Ma Jingyuan Song Ru Xiao Luk Vandenberghe Feng Zhang Patricia A. D’Amore Hetian Lei
author_facet	Xionggao Huang Guohong Zhou Wenyi Wu Yajian Duan Gaoen Ma Jingyuan Song Ru Xiao Luk Vandenberghe Feng Zhang Patricia A. D’Amore Hetian Lei
author_sort	Xionggao Huang
title	Genome editing abrogates angiogenesis in vivo
title_short	Genome editing abrogates angiogenesis in vivo
title_full	Genome editing abrogates angiogenesis in vivo
title_fullStr	Genome editing abrogates angiogenesis in vivo
title_full_unstemmed	Genome editing abrogates angiogenesis in vivo
title_sort	genome editing abrogates angiogenesis in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f981fc904c1b403e9521fe12e9013ee3
work_keys_str_mv	AT xionggaohuang genomeeditingabrogatesangiogenesisinvivo AT guohongzhou genomeeditingabrogatesangiogenesisinvivo AT wenyiwu genomeeditingabrogatesangiogenesisinvivo AT yajianduan genomeeditingabrogatesangiogenesisinvivo AT gaoenma genomeeditingabrogatesangiogenesisinvivo AT jingyuansong genomeeditingabrogatesangiogenesisinvivo AT ruxiao genomeeditingabrogatesangiogenesisinvivo AT lukvandenberghe genomeeditingabrogatesangiogenesisinvivo AT fengzhang genomeeditingabrogatesangiogenesisinvivo AT patriciaadamore genomeeditingabrogatesangiogenesisinvivo AT hetianlei genomeeditingabrogatesangiogenesisinvivo
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Genome editing abrogates angiogenesis in vivo

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