3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth

Yiqun Zhang,1 Wei Yu,1 Zhaoyu Ba,2 Shusen Cui,1 Jie Wei,3 Hong Li4 1Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China; 2Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; 3Key Laboratory...

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Autores principales:	Zhang Y, Yu W, Ba Z, Cui S, Wei J, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	3D-printed scaffolds polymer based composite biocompatibility degradability osteogenesis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9821392781f444dba97044b2a39938e
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spelling	oai:doaj.org-article:f9821392781f444dba97044b2a39938e2021-12-02T01:36:44Z3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth1178-2013https://doaj.org/article/f9821392781f444dba97044b2a39938e2018-09-01T00:00:00Zhttps://www.dovepress.com/3d-printed-scaffolds-of-mesoporous-bioglassgliadinpolycaprolactone-ter-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yiqun Zhang,1 Wei Yu,1 Zhaoyu Ba,2 Shusen Cui,1 Jie Wei,3 Hong Li4 1Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China; 2Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China; 4College of Physical Science and Technology, Sichuan University, Chengdu 610041, China Background: Due to the increasing number of patients with bone defects, bone nonunion and osteomyelitis, tumor and congenital diseases, bone repair has become an urgent problem to be solved.Methods: In this study, the 3D-printed scaffolds of ternary composites containing mesoporous bioglass fibers of magnesium calcium silicate (mMCS), gliadin (GA) and polycaprolactone (PCL) were fabricated using a 3D Bioprinter.Results: The compressive strength and in vitro degradability of the mMCS/GA/PCL composites (MGPC) scaffolds were improved with the increase of mMCS content. In addition, the attachment and proliferation of MC3T3-E1 cells on the scaffolds were significantly promoted with the increase of mMCS content. Moreover, the cells with normal phenotype attached and spread well on the scaffolds surfaces, indicating good cytocompatibility. The scaffolds were implanted into the femur defects of rabbits, and the results demonstrated that the scaffold containing mMCS stimulated new bone formation and ingrowth into the scaffolds through scaffolds degradation in vivo. Moreover, the expression of type I collagen into scaffolds was enhanced with the increase of mMCS content.Conclusion: The 3D-printed MGPC scaffold with controllable architecture, good biocompatibility, high compressive strength, proper degradability and excellent in vivo osteogenesis has great potential for bone regeneration. Keywords: ternary composites, polymer-based composite, biocompatibility, cytocompatibility, osteogenesisZhang YYu WBa ZCui SWei JLi HDove Medical Pressarticle3D-printed scaffoldspolymer based compositebiocompatibilitydegradabilityosteogenesisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5433-5447 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D-printed scaffolds polymer based composite biocompatibility degradability osteogenesis Medicine (General) R5-920
spellingShingle	3D-printed scaffolds polymer based composite biocompatibility degradability osteogenesis Medicine (General) R5-920 Zhang Y Yu W Ba Z Cui S Wei J Li H 3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
description	Yiqun Zhang,1 Wei Yu,1 Zhaoyu Ba,2 Shusen Cui,1 Jie Wei,3 Hong Li4 1Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China; 2Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China; 4College of Physical Science and Technology, Sichuan University, Chengdu 610041, China Background: Due to the increasing number of patients with bone defects, bone nonunion and osteomyelitis, tumor and congenital diseases, bone repair has become an urgent problem to be solved.Methods: In this study, the 3D-printed scaffolds of ternary composites containing mesoporous bioglass fibers of magnesium calcium silicate (mMCS), gliadin (GA) and polycaprolactone (PCL) were fabricated using a 3D Bioprinter.Results: The compressive strength and in vitro degradability of the mMCS/GA/PCL composites (MGPC) scaffolds were improved with the increase of mMCS content. In addition, the attachment and proliferation of MC3T3-E1 cells on the scaffolds were significantly promoted with the increase of mMCS content. Moreover, the cells with normal phenotype attached and spread well on the scaffolds surfaces, indicating good cytocompatibility. The scaffolds were implanted into the femur defects of rabbits, and the results demonstrated that the scaffold containing mMCS stimulated new bone formation and ingrowth into the scaffolds through scaffolds degradation in vivo. Moreover, the expression of type I collagen into scaffolds was enhanced with the increase of mMCS content.Conclusion: The 3D-printed MGPC scaffold with controllable architecture, good biocompatibility, high compressive strength, proper degradability and excellent in vivo osteogenesis has great potential for bone regeneration. Keywords: ternary composites, polymer-based composite, biocompatibility, cytocompatibility, osteogenesis
format	article
author	Zhang Y Yu W Ba Z Cui S Wei J Li H
author_facet	Zhang Y Yu W Ba Z Cui S Wei J Li H
author_sort	Zhang Y
title	3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
title_short	3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
title_full	3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
title_fullStr	3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
title_full_unstemmed	3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
title_sort	3d-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f9821392781f444dba97044b2a39938e
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3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth

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