Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activatio...

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Autores principales: Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/f985f3f45e114476aff8ed39645b53e3
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Sumario:Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activation.

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