Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activatio...

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Autores principales:	Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f985f3f45e114476aff8ed39645b53e3
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spelling	oai:doaj.org-article:f985f3f45e114476aff8ed39645b53e32021-12-02T17:40:24ZSingle-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma10.1038/s41467-021-24010-12041-1723https://doaj.org/article/f985f3f45e114476aff8ed39645b53e32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24010-1https://doaj.org/toc/2041-1723Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activation.Daniel Wai-Hung HoYu-Man TsuiLo-Kong ChanKaren Man-Fong SzeXin ZhangJacinth Wing-Sum CheuYung-Tuen ChiuJoyce Man-Fong LeeAlbert Chi-Yan ChanElaine Tin-Yan CheungDerek Tsz-Wai YauNam-Hung ChiaIrene Lai-Oi LoPak-Chung ShamTan-To CheungCarmen Chak-Lui WongIrene Oi-Lin NgNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Wai-Hung Ho Yu-Man Tsui Lo-Kong Chan Karen Man-Fong Sze Xin Zhang Jacinth Wing-Sum Cheu Yung-Tuen Chiu Joyce Man-Fong Lee Albert Chi-Yan Chan Elaine Tin-Yan Cheung Derek Tsz-Wai Yau Nam-Hung Chia Irene Lai-Oi Lo Pak-Chung Sham Tan-To Cheung Carmen Chak-Lui Wong Irene Oi-Lin Ng Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
description	Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activation.
format	article
author	Daniel Wai-Hung Ho Yu-Man Tsui Lo-Kong Chan Karen Man-Fong Sze Xin Zhang Jacinth Wing-Sum Cheu Yung-Tuen Chiu Joyce Man-Fong Lee Albert Chi-Yan Chan Elaine Tin-Yan Cheung Derek Tsz-Wai Yau Nam-Hung Chia Irene Lai-Oi Lo Pak-Chung Sham Tan-To Cheung Carmen Chak-Lui Wong Irene Oi-Lin Ng
author_facet	Daniel Wai-Hung Ho Yu-Man Tsui Lo-Kong Chan Karen Man-Fong Sze Xin Zhang Jacinth Wing-Sum Cheu Yung-Tuen Chiu Joyce Man-Fong Lee Albert Chi-Yan Chan Elaine Tin-Yan Cheung Derek Tsz-Wai Yau Nam-Hung Chia Irene Lai-Oi Lo Pak-Chung Sham Tan-To Cheung Carmen Chak-Lui Wong Irene Oi-Lin Ng
author_sort	Daniel Wai-Hung Ho
title	Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
title_short	Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
title_full	Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
title_fullStr	Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
title_full_unstemmed	Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
title_sort	single-cell rna sequencing shows the immunosuppressive landscape and tumor heterogeneity of hbv-associated hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f985f3f45e114476aff8ed39645b53e3
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Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

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