The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

High cholesterol is a risk factor for breast cancer recurrence. Here the authors show that cholesterol promotes breast cancer metastasis via its metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal metastatic sites, thus promoting an immune suppressive env...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell, Erik R. Nelson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f990d083ec9e44f8ab4139f27a94e9ba
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f990d083ec9e44f8ab4139f27a94e9ba
record_format dspace
spelling oai:doaj.org-article:f990d083ec9e44f8ab4139f27a94e9ba2021-12-02T14:40:37ZThe cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells10.1038/s41467-017-00910-z2041-1723https://doaj.org/article/f990d083ec9e44f8ab4139f27a94e9ba2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00910-zhttps://doaj.org/toc/2041-1723High cholesterol is a risk factor for breast cancer recurrence. Here the authors show that cholesterol promotes breast cancer metastasis via its metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal metastatic sites, thus promoting an immune suppressive environment.Amy E. BaekYen-Rei A. YuSisi HeSuzanne E. WardellChing-Yi ChangSanghoon KwonRuchita V. PillaiHannah B. McDowellJ. Will ThompsonLaura G. DuboisPatrick M. SullivanJongsook K. KemperMichael D. GunnDonald P. McDonnellErik R. NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amy E. Baek
Yen-Rei A. Yu
Sisi He
Suzanne E. Wardell
Ching-Yi Chang
Sanghoon Kwon
Ruchita V. Pillai
Hannah B. McDowell
J. Will Thompson
Laura G. Dubois
Patrick M. Sullivan
Jongsook K. Kemper
Michael D. Gunn
Donald P. McDonnell
Erik R. Nelson
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
description High cholesterol is a risk factor for breast cancer recurrence. Here the authors show that cholesterol promotes breast cancer metastasis via its metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal metastatic sites, thus promoting an immune suppressive environment.
format article
author Amy E. Baek
Yen-Rei A. Yu
Sisi He
Suzanne E. Wardell
Ching-Yi Chang
Sanghoon Kwon
Ruchita V. Pillai
Hannah B. McDowell
J. Will Thompson
Laura G. Dubois
Patrick M. Sullivan
Jongsook K. Kemper
Michael D. Gunn
Donald P. McDonnell
Erik R. Nelson
author_facet Amy E. Baek
Yen-Rei A. Yu
Sisi He
Suzanne E. Wardell
Ching-Yi Chang
Sanghoon Kwon
Ruchita V. Pillai
Hannah B. McDowell
J. Will Thompson
Laura G. Dubois
Patrick M. Sullivan
Jongsook K. Kemper
Michael D. Gunn
Donald P. McDonnell
Erik R. Nelson
author_sort Amy E. Baek
title The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
title_short The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
title_full The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
title_fullStr The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
title_full_unstemmed The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
title_sort cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f990d083ec9e44f8ab4139f27a94e9ba
work_keys_str_mv AT amyebaek thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT yenreiayu thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT sisihe thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT suzanneewardell thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT chingyichang thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT sanghoonkwon thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT ruchitavpillai thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT hannahbmcdowell thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT jwillthompson thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT lauragdubois thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT patrickmsullivan thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT jongsookkkemper thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT michaeldgunn thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT donaldpmcdonnell thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT erikrnelson thecholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT amyebaek cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT yenreiayu cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT sisihe cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT suzanneewardell cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT chingyichang cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT sanghoonkwon cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT ruchitavpillai cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT hannahbmcdowell cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT jwillthompson cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT lauragdubois cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT patrickmsullivan cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT jongsookkkemper cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT michaeldgunn cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT donaldpmcdonnell cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
AT erikrnelson cholesterolmetabolite27hydroxycholesterolfacilitatesbreastcancermetastasisthroughitsactionsonimmunecells
_version_ 1718390274181300224

Ejemplares similares