Reviewing the history of HIV-1: spread of subtype B in the Americas.

The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in sprea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dennis Maletich Junqueira, Rúbia Marília de Medeiros, Maria Cristina Cotta Matte, Leonardo Augusto Luvison Araújo, Jose Artur Bogo Chies, Patricia Ashton-Prolla, Sabrina Esteves de Matos Almeida
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f992c058579b4094acabb75952b481e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f992c058579b4094acabb75952b481e4
record_format	dspace
spelling	oai:doaj.org-article:f992c058579b4094acabb75952b481e42021-11-18T07:33:40ZReviewing the history of HIV-1: spread of subtype B in the Americas.1932-620310.1371/journal.pone.0027489https://doaj.org/article/f992c058579b4094acabb75952b481e42011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132104/?tool=EBIhttps://doaj.org/toc/1932-6203The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in spreading the virus to the United States. However, the exact pathways taken during the establishment of the pandemic in the Americas remain unclear. Here, we propose a geographical scenario for the dissemination of HIV-1B in the Americas, based on phylogenetic and genetic statistical analyses of 313 available sequences of the pol gene from 27 countries. Maximum likelihood and bayesian inference methods were used to explore the phylogenetic relationships between HIV-1B sequences, and molecular variance estimates were analyzed to infer the genetic structure of the viral population. We found that the initial dissemination and subsequent spread of subtype B in the Americas occurred via a single introduction event in the Caribbean around 1964 (1950-1967). Phylogenetic trees present evidence of several primary outbreaks in countries in South America, directly seeded by the Caribbean epidemic. Cuba is an exception insofar as its epidemic seems to have been introduced from South America. One clade comprising isolates from different countries emerged in the most-derived branches, reflecting the intense circulation of the virus throughout the American continents. Statistical analysis supports the genetic compartmentalization of the virus among the Americas, with a close relationship between the South American and Caribbean epidemics. These findings reflect the complex establishment of the HIV-1B pandemic and contribute to our understanding between the migration process of human populations and virus diffusion.Dennis Maletich JunqueiraRúbia Marília de MedeirosMaria Cristina Cotta MatteLeonardo Augusto Luvison AraújoJose Artur Bogo ChiesPatricia Ashton-ProllaSabrina Esteves de Matos AlmeidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27489 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dennis Maletich Junqueira Rúbia Marília de Medeiros Maria Cristina Cotta Matte Leonardo Augusto Luvison Araújo Jose Artur Bogo Chies Patricia Ashton-Prolla Sabrina Esteves de Matos Almeida Reviewing the history of HIV-1: spread of subtype B in the Americas.
description	The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in spreading the virus to the United States. However, the exact pathways taken during the establishment of the pandemic in the Americas remain unclear. Here, we propose a geographical scenario for the dissemination of HIV-1B in the Americas, based on phylogenetic and genetic statistical analyses of 313 available sequences of the pol gene from 27 countries. Maximum likelihood and bayesian inference methods were used to explore the phylogenetic relationships between HIV-1B sequences, and molecular variance estimates were analyzed to infer the genetic structure of the viral population. We found that the initial dissemination and subsequent spread of subtype B in the Americas occurred via a single introduction event in the Caribbean around 1964 (1950-1967). Phylogenetic trees present evidence of several primary outbreaks in countries in South America, directly seeded by the Caribbean epidemic. Cuba is an exception insofar as its epidemic seems to have been introduced from South America. One clade comprising isolates from different countries emerged in the most-derived branches, reflecting the intense circulation of the virus throughout the American continents. Statistical analysis supports the genetic compartmentalization of the virus among the Americas, with a close relationship between the South American and Caribbean epidemics. These findings reflect the complex establishment of the HIV-1B pandemic and contribute to our understanding between the migration process of human populations and virus diffusion.
format	article
author	Dennis Maletich Junqueira Rúbia Marília de Medeiros Maria Cristina Cotta Matte Leonardo Augusto Luvison Araújo Jose Artur Bogo Chies Patricia Ashton-Prolla Sabrina Esteves de Matos Almeida
author_facet	Dennis Maletich Junqueira Rúbia Marília de Medeiros Maria Cristina Cotta Matte Leonardo Augusto Luvison Araújo Jose Artur Bogo Chies Patricia Ashton-Prolla Sabrina Esteves de Matos Almeida
author_sort	Dennis Maletich Junqueira
title	Reviewing the history of HIV-1: spread of subtype B in the Americas.
title_short	Reviewing the history of HIV-1: spread of subtype B in the Americas.
title_full	Reviewing the history of HIV-1: spread of subtype B in the Americas.
title_fullStr	Reviewing the history of HIV-1: spread of subtype B in the Americas.
title_full_unstemmed	Reviewing the history of HIV-1: spread of subtype B in the Americas.
title_sort	reviewing the history of hiv-1: spread of subtype b in the americas.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f992c058579b4094acabb75952b481e4
work_keys_str_mv	AT dennismaletichjunqueira reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT rubiamariliademedeiros reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT mariacristinacottamatte reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT leonardoaugustoluvisonaraujo reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT josearturbogochies reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT patriciaashtonprolla reviewingthehistoryofhiv1spreadofsubtypebintheamericas AT sabrinaestevesdematosalmeida reviewingthehistoryofhiv1spreadofsubtypebintheamericas
_version_	1718423324522971136

Reviewing the history of HIV-1: spread of subtype B in the Americas.

Ejemplares similares