Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents

There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing information. We report here that a 14-day course of...

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Autores principales:	Aliza A. Le, Julian Quintanilla, Mohammad Amani, Daniele Piomelli, Gary Lynch, Christine M. Gall
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	THC hippocampus CA1 Lateral perforant path Cannabinoid Spatial learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f992fbb413a144c6ba177736a2c214ac
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spelling	oai:doaj.org-article:f992fbb413a144c6ba177736a2c214ac2021-12-04T04:33:14ZPersistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents1095-953X10.1016/j.nbd.2021.105565https://doaj.org/article/f992fbb413a144c6ba177736a2c214ac2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121003144https://doaj.org/toc/1095-953XThere is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing information. We report here that a 14-day course of daily Δ9-tetrahydrocannabinol treatments administered to adolescent rats and mice (aTHC) leads to profound but selective deficits in synaptic plasticity in two axonal systems in female, and to lesser extent male, hippocampus as assessed in adulthood. Adolescent-THC exposure did not alter basic synaptic transmission (input/output curves) and had only modest effects on frequency facilitation. Nevertheless, aTHC severely impaired the endocannabinoid-dependent long-term potentiation in the lateral perforant path in females of both species, and in male mice; this was reliably associated with impaired acquisition of a component of episodic memory that depends on lateral perforant path function. Potentiation in the Schaffer-commissural (S-C) projection to field CA1 was disrupted by aTHC treatment in females only and this was associated with both a deficit in estrogen effects on S-C synaptic responses and impairments to CA1-dependent spatial (object location) memory. In all the results demonstrate sexually dimorphic and projection system-specific effects of aTHC exposure that could underlie discrete effects of early life cannabinoid usage on adult cognitive function. Moreover they suggest that some of the enduring, sexually dimorphic effects of cannabis use reflect changes in synaptic estrogen action.Aliza A. LeJulian QuintanillaMohammad AmaniDaniele PiomelliGary LynchChristine M. GallElsevierarticleTHChippocampusCA1Lateral perforant pathCannabinoidSpatial learningNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 162, Iss , Pp 105565- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	THC hippocampus CA1 Lateral perforant path Cannabinoid Spatial learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	THC hippocampus CA1 Lateral perforant path Cannabinoid Spatial learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Aliza A. Le Julian Quintanilla Mohammad Amani Daniele Piomelli Gary Lynch Christine M. Gall Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
description	There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing information. We report here that a 14-day course of daily Δ9-tetrahydrocannabinol treatments administered to adolescent rats and mice (aTHC) leads to profound but selective deficits in synaptic plasticity in two axonal systems in female, and to lesser extent male, hippocampus as assessed in adulthood. Adolescent-THC exposure did not alter basic synaptic transmission (input/output curves) and had only modest effects on frequency facilitation. Nevertheless, aTHC severely impaired the endocannabinoid-dependent long-term potentiation in the lateral perforant path in females of both species, and in male mice; this was reliably associated with impaired acquisition of a component of episodic memory that depends on lateral perforant path function. Potentiation in the Schaffer-commissural (S-C) projection to field CA1 was disrupted by aTHC treatment in females only and this was associated with both a deficit in estrogen effects on S-C synaptic responses and impairments to CA1-dependent spatial (object location) memory. In all the results demonstrate sexually dimorphic and projection system-specific effects of aTHC exposure that could underlie discrete effects of early life cannabinoid usage on adult cognitive function. Moreover they suggest that some of the enduring, sexually dimorphic effects of cannabis use reflect changes in synaptic estrogen action.
format	article
author	Aliza A. Le Julian Quintanilla Mohammad Amani Daniele Piomelli Gary Lynch Christine M. Gall
author_facet	Aliza A. Le Julian Quintanilla Mohammad Amani Daniele Piomelli Gary Lynch Christine M. Gall
author_sort	Aliza A. Le
title	Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
title_short	Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
title_full	Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
title_fullStr	Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
title_full_unstemmed	Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
title_sort	persistent sexually dimorphic effects of adolescent thc exposure on hippocampal synaptic plasticity and episodic memory in rodents
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/f992fbb413a144c6ba177736a2c214ac
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_version_	1718373008242900992

Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents

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