Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists
Combining molecular modeling and in vitro bioassays, Sokkar et al. provide an understanding of how EPI-X4, an endogenous peptide antagonist, interacts with its receptor CXCR4. With computational model, validated by mutagenesis studies, they design a series of derivatives with optimized receptor anta...
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Auteurs principaux: | Pandian Sokkar, Mirja Harms, Christina Stürzel, Andrea Gilg, Gönül Kizilsavas, Martina Raasholm, Nico Preising, Manfred Wagner, Frank Kirchhoff, Ludger Ständker, Gilbert Weidinger, Benjamin Mayer, Jan Münch, Elsa Sanchez-Garcia |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
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Accès en ligne: | https://doaj.org/article/f993d3d26776456ebe0fc89bf8e4a5df |
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