Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions i...

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Autores principales: Anne Dirkse, Anna Golebiewska, Thomas Buder, Petr V. Nazarov, Arnaud Muller, Suresh Poovathingal, Nicolaas H. C. Brons, Sonia Leite, Nicolas Sauvageot, Dzjemma Sarkisjan, Mathieu Seyfrid, Sabrina Fritah, Daniel Stieber, Alessandro Michelucci, Frank Hertel, Christel Herold-Mende, Francisco Azuaje, Alexander Skupin, Rolf Bjerkvig, Andreas Deutsch, Anja Voss-Böhme, Simone P. Niclou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f9953d80d7214efbbab8832d2c810d81
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spelling oai:doaj.org-article:f9953d80d7214efbbab8832d2c810d812021-12-02T15:35:53ZStem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment10.1038/s41467-019-09853-z2041-1723https://doaj.org/article/f9953d80d7214efbbab8832d2c810d812019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09853-zhttps://doaj.org/toc/2041-1723Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions induced by the microenvironment.Anne DirkseAnna GolebiewskaThomas BuderPetr V. NazarovArnaud MullerSuresh PoovathingalNicolaas H. C. BronsSonia LeiteNicolas SauvageotDzjemma SarkisjanMathieu SeyfridSabrina FritahDaniel StieberAlessandro MichelucciFrank HertelChristel Herold-MendeFrancisco AzuajeAlexander SkupinRolf BjerkvigAndreas DeutschAnja Voss-BöhmeSimone P. NiclouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anne Dirkse
Anna Golebiewska
Thomas Buder
Petr V. Nazarov
Arnaud Muller
Suresh Poovathingal
Nicolaas H. C. Brons
Sonia Leite
Nicolas Sauvageot
Dzjemma Sarkisjan
Mathieu Seyfrid
Sabrina Fritah
Daniel Stieber
Alessandro Michelucci
Frank Hertel
Christel Herold-Mende
Francisco Azuaje
Alexander Skupin
Rolf Bjerkvig
Andreas Deutsch
Anja Voss-Böhme
Simone P. Niclou
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
description Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions induced by the microenvironment.
format article
author Anne Dirkse
Anna Golebiewska
Thomas Buder
Petr V. Nazarov
Arnaud Muller
Suresh Poovathingal
Nicolaas H. C. Brons
Sonia Leite
Nicolas Sauvageot
Dzjemma Sarkisjan
Mathieu Seyfrid
Sabrina Fritah
Daniel Stieber
Alessandro Michelucci
Frank Hertel
Christel Herold-Mende
Francisco Azuaje
Alexander Skupin
Rolf Bjerkvig
Andreas Deutsch
Anja Voss-Böhme
Simone P. Niclou
author_facet Anne Dirkse
Anna Golebiewska
Thomas Buder
Petr V. Nazarov
Arnaud Muller
Suresh Poovathingal
Nicolaas H. C. Brons
Sonia Leite
Nicolas Sauvageot
Dzjemma Sarkisjan
Mathieu Seyfrid
Sabrina Fritah
Daniel Stieber
Alessandro Michelucci
Frank Hertel
Christel Herold-Mende
Francisco Azuaje
Alexander Skupin
Rolf Bjerkvig
Andreas Deutsch
Anja Voss-Böhme
Simone P. Niclou
author_sort Anne Dirkse
title Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
title_short Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
title_full Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
title_fullStr Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
title_full_unstemmed Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
title_sort stem cell-associated heterogeneity in glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f9953d80d7214efbbab8832d2c810d81
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