Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road

It is a common pathway for patients with the behavioral variant of frontotemporal dementia (bvFTD) to be first misdiagnosed with a primary psychiatric disorder, a considerable proportion of them being diagnosed with bipolar disorder (BD). Conversely, not rarely patients presenting in late life with...

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Autores principales:	Mari N. Maia da Silva, Fábio Henrique de Gobbi Porto, Pedro Maranhão Gomes Lopes, Catarina Sodré de Castro Prado, Norberto Anízio Ferreira Frota, Candida Helena Lopes Alves, Gilberto Sousa Alves
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bipolar disorder frontotemporal dementia aging neurodegeneration frontal syndrome neuropsychiatry Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f99802063e474db3af18db9cc6761468
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spelling	oai:doaj.org-article:f99802063e474db3af18db9cc67614682021-12-02T09:30:36ZFrontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road1664-064010.3389/fpsyt.2021.768722https://doaj.org/article/f99802063e474db3af18db9cc67614682021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.768722/fullhttps://doaj.org/toc/1664-0640It is a common pathway for patients with the behavioral variant of frontotemporal dementia (bvFTD) to be first misdiagnosed with a primary psychiatric disorder, a considerable proportion of them being diagnosed with bipolar disorder (BD). Conversely, not rarely patients presenting in late life with a first episode of mania or atypically severe depression are initially considered to have dementia before the diagnosis of late-onset BD is reached. Beyond some shared features that make these conditions particularly prone to confusion, especially in the elderly, the relationship between bvFTD and BD is far from simple. Patients with BD often have cognitive complaints as part of their psychiatric disorder but are at an increased risk of developing dementia, including FTD. Likewise, apathy and disinhibition, common features of depression and mania, respectively, are among the core features of the bvFTD syndrome, not to mention that depression may coexist with dementia. In this article, we take advantage of the current knowledge on the neurobiology of these two nosologic entities to review their historical and conceptual interplay, highlighting the clinical, genetic and neuroimaging features that may be shared by both disorders or unique to each of them.Mari N. Maia da SilvaFábio Henrique de Gobbi PortoPedro Maranhão Gomes LopesCatarina Sodré de Castro PradoNorberto Anízio Ferreira FrotaCandida Helena Lopes AlvesGilberto Sousa AlvesGilberto Sousa AlvesFrontiers Media S.A.articlebipolar disorderfrontotemporal dementiaagingneurodegenerationfrontal syndromeneuropsychiatryPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder frontotemporal dementia aging neurodegeneration frontal syndrome neuropsychiatry Psychiatry RC435-571
spellingShingle	bipolar disorder frontotemporal dementia aging neurodegeneration frontal syndrome neuropsychiatry Psychiatry RC435-571 Mari N. Maia da Silva Fábio Henrique de Gobbi Porto Pedro Maranhão Gomes Lopes Catarina Sodré de Castro Prado Norberto Anízio Ferreira Frota Candida Helena Lopes Alves Gilberto Sousa Alves Gilberto Sousa Alves Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
description	It is a common pathway for patients with the behavioral variant of frontotemporal dementia (bvFTD) to be first misdiagnosed with a primary psychiatric disorder, a considerable proportion of them being diagnosed with bipolar disorder (BD). Conversely, not rarely patients presenting in late life with a first episode of mania or atypically severe depression are initially considered to have dementia before the diagnosis of late-onset BD is reached. Beyond some shared features that make these conditions particularly prone to confusion, especially in the elderly, the relationship between bvFTD and BD is far from simple. Patients with BD often have cognitive complaints as part of their psychiatric disorder but are at an increased risk of developing dementia, including FTD. Likewise, apathy and disinhibition, common features of depression and mania, respectively, are among the core features of the bvFTD syndrome, not to mention that depression may coexist with dementia. In this article, we take advantage of the current knowledge on the neurobiology of these two nosologic entities to review their historical and conceptual interplay, highlighting the clinical, genetic and neuroimaging features that may be shared by both disorders or unique to each of them.
format	article
author	Mari N. Maia da Silva Fábio Henrique de Gobbi Porto Pedro Maranhão Gomes Lopes Catarina Sodré de Castro Prado Norberto Anízio Ferreira Frota Candida Helena Lopes Alves Gilberto Sousa Alves Gilberto Sousa Alves
author_facet	Mari N. Maia da Silva Fábio Henrique de Gobbi Porto Pedro Maranhão Gomes Lopes Catarina Sodré de Castro Prado Norberto Anízio Ferreira Frota Candida Helena Lopes Alves Gilberto Sousa Alves Gilberto Sousa Alves
author_sort	Mari N. Maia da Silva
title	Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
title_short	Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
title_full	Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
title_fullStr	Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
title_full_unstemmed	Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road
title_sort	frontotemporal dementia and late-onset bipolar disorder: the many directions of a busy road
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f99802063e474db3af18db9cc6761468
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Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road

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