Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasio...

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Autores principales: Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zemin Zhang, Jiafu Ji, Xiaofeng Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f99a7ef680884d08bdf077e2681635d7
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spelling oai:doaj.org-article:f99a7ef680884d08bdf077e2681635d72021-12-02T15:38:36ZAdenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation10.1038/ncomms153082041-1723https://doaj.org/article/f99a7ef680884d08bdf077e2681635d72017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15308https://doaj.org/toc/2041-1723Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs.Yapeng JiChuanzhen YangZefang TangYongfeng YangYonglu TianHongwei YaoXi ZhuZemin ZhangJiafu JiXiaofeng ZhengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yapeng Ji
Chuanzhen Yang
Zefang Tang
Yongfeng Yang
Yonglu Tian
Hongwei Yao
Xi Zhu
Zemin Zhang
Jiafu Ji
Xiaofeng Zheng
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
description Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs.
format article
author Yapeng Ji
Chuanzhen Yang
Zefang Tang
Yongfeng Yang
Yonglu Tian
Hongwei Yao
Xi Zhu
Zemin Zhang
Jiafu Ji
Xiaofeng Zheng
author_facet Yapeng Ji
Chuanzhen Yang
Zefang Tang
Yongfeng Yang
Yonglu Tian
Hongwei Yao
Xi Zhu
Zemin Zhang
Jiafu Ji
Xiaofeng Zheng
author_sort Yapeng Ji
title Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
title_short Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
title_full Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
title_fullStr Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
title_full_unstemmed Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
title_sort adenylate kinase hcinap determines self-renewal of colorectal cancer stem cells by facilitating ldha phosphorylation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f99a7ef680884d08bdf077e2681635d7
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