Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasio...
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Nature Portfolio
2017
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oai:doaj.org-article:f99a7ef680884d08bdf077e2681635d72021-12-02T15:38:36ZAdenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation10.1038/ncomms153082041-1723https://doaj.org/article/f99a7ef680884d08bdf077e2681635d72017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15308https://doaj.org/toc/2041-1723Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs.Yapeng JiChuanzhen YangZefang TangYongfeng YangYonglu TianHongwei YaoXi ZhuZemin ZhangJiafu JiXiaofeng ZhengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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Science Q Yapeng Ji Chuanzhen Yang Zefang Tang Yongfeng Yang Yonglu Tian Hongwei Yao Xi Zhu Zemin Zhang Jiafu Ji Xiaofeng Zheng Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
description |
Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs. |
format |
article |
author |
Yapeng Ji Chuanzhen Yang Zefang Tang Yongfeng Yang Yonglu Tian Hongwei Yao Xi Zhu Zemin Zhang Jiafu Ji Xiaofeng Zheng |
author_facet |
Yapeng Ji Chuanzhen Yang Zefang Tang Yongfeng Yang Yonglu Tian Hongwei Yao Xi Zhu Zemin Zhang Jiafu Ji Xiaofeng Zheng |
author_sort |
Yapeng Ji |
title |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
title_short |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
title_full |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
title_fullStr |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
title_full_unstemmed |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
title_sort |
adenylate kinase hcinap determines self-renewal of colorectal cancer stem cells by facilitating ldha phosphorylation |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/f99a7ef680884d08bdf077e2681635d7 |
work_keys_str_mv |
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_version_ |
1718386149598167040 |