Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation

Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical...

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Autores principales: Meira J, Marques ML, Falcão-Reis F, Rebelo Gomes E, Carneiro Â
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:f99a84d0e0074e989c438ef5c2bb22a42021-12-02T11:02:09ZImmediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation1177-5483https://doaj.org/article/f99a84d0e0074e989c438ef5c2bb22a42020-01-01T00:00:00Zhttps://www.dovepress.com/immediate-reactions-to-fluorescein-and-indocyanine-green-in-retinal-an-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 3Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal*These authors contributed equally to this workCorrespondence: Jorge MeiraDepartment of Ophthalmology of São João Hospital, Avenida Prof. Hernâni Monteiro, Porto 4202 – 451, PortugalTel +351225512100Fax +351225513669Email jorgesmeira@gmail.comIntroduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and non-specific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure.Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG.Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms “fluorescein”, “Indocyanine green”, “ophthalmic dyes”, “retinal angiography”, “adverse reactions”, and “allergic reaction”.Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.Keywords: fluorescein, indocyanine green, ophthalmic dyes, retinal angiography, adverse reactions, hypersensitivity reactionMeira JMarques MLFalcão-Reis FRebelo Gomes ECarneiro ÂDove Medical Pressarticlefluoresceinindocyanine greenophthalmic dyesretinal angiographyadverse reactionshypersensitivity reaction.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 171-178 (2020)
institution DOAJ
collection DOAJ
language EN
topic fluorescein
indocyanine green
ophthalmic dyes
retinal angiography
adverse reactions
hypersensitivity reaction.
Ophthalmology
RE1-994
spellingShingle fluorescein
indocyanine green
ophthalmic dyes
retinal angiography
adverse reactions
hypersensitivity reaction.
Ophthalmology
RE1-994
Meira J
Marques ML
Falcão-Reis F
Rebelo Gomes E
Carneiro Â
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
description Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 3Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal*These authors contributed equally to this workCorrespondence: Jorge MeiraDepartment of Ophthalmology of São João Hospital, Avenida Prof. Hernâni Monteiro, Porto 4202 – 451, PortugalTel +351225512100Fax +351225513669Email jorgesmeira@gmail.comIntroduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and non-specific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure.Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG.Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms “fluorescein”, “Indocyanine green”, “ophthalmic dyes”, “retinal angiography”, “adverse reactions”, and “allergic reaction”.Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.Keywords: fluorescein, indocyanine green, ophthalmic dyes, retinal angiography, adverse reactions, hypersensitivity reaction
format article
author Meira J
Marques ML
Falcão-Reis F
Rebelo Gomes E
Carneiro Â
author_facet Meira J
Marques ML
Falcão-Reis F
Rebelo Gomes E
Carneiro Â
author_sort Meira J
title Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
title_short Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
title_full Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
title_fullStr Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
title_full_unstemmed Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
title_sort immediate reactions to fluorescein and indocyanine green in retinal angiography: review of literature and proposal for patient’s evaluation
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/f99a84d0e0074e989c438ef5c2bb22a4
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