Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation
Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical...
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Dove Medical Press
2020
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oai:doaj.org-article:f99a84d0e0074e989c438ef5c2bb22a42021-12-02T11:02:09ZImmediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation1177-5483https://doaj.org/article/f99a84d0e0074e989c438ef5c2bb22a42020-01-01T00:00:00Zhttps://www.dovepress.com/immediate-reactions-to-fluorescein-and-indocyanine-green-in-retinal-an-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 3Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal*These authors contributed equally to this workCorrespondence: Jorge MeiraDepartment of Ophthalmology of São João Hospital, Avenida Prof. Hernâni Monteiro, Porto 4202 – 451, PortugalTel +351225512100Fax +351225513669Email jorgesmeira@gmail.comIntroduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and non-specific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure.Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG.Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms “fluorescein”, “Indocyanine green”, “ophthalmic dyes”, “retinal angiography”, “adverse reactions”, and “allergic reaction”.Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.Keywords: fluorescein, indocyanine green, ophthalmic dyes, retinal angiography, adverse reactions, hypersensitivity reactionMeira JMarques MLFalcão-Reis FRebelo Gomes ECarneiro ÂDove Medical Pressarticlefluoresceinindocyanine greenophthalmic dyesretinal angiographyadverse reactionshypersensitivity reaction.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 171-178 (2020) |
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fluorescein indocyanine green ophthalmic dyes retinal angiography adverse reactions hypersensitivity reaction. Ophthalmology RE1-994 |
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fluorescein indocyanine green ophthalmic dyes retinal angiography adverse reactions hypersensitivity reaction. Ophthalmology RE1-994 Meira J Marques ML Falcão-Reis F Rebelo Gomes E Carneiro  Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
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Jorge Meira, 1,* Maria Luís Marques, 2,* Fernando Falcão-Reis, 1, 3 Eva Rebelo Gomes, 2 Ângela Carneiro 1, 3 1Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal; 2Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 3Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal*These authors contributed equally to this workCorrespondence: Jorge MeiraDepartment of Ophthalmology of São João Hospital, Avenida Prof. Hernâni Monteiro, Porto 4202 – 451, PortugalTel +351225512100Fax +351225513669Email jorgesmeira@gmail.comIntroduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and non-specific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure.Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG.Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms “fluorescein”, “Indocyanine green”, “ophthalmic dyes”, “retinal angiography”, “adverse reactions”, and “allergic reaction”.Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.Keywords: fluorescein, indocyanine green, ophthalmic dyes, retinal angiography, adverse reactions, hypersensitivity reaction |
format |
article |
author |
Meira J Marques ML Falcão-Reis F Rebelo Gomes E Carneiro  |
author_facet |
Meira J Marques ML Falcão-Reis F Rebelo Gomes E Carneiro  |
author_sort |
Meira J |
title |
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
title_short |
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
title_full |
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
title_fullStr |
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
title_full_unstemmed |
Immediate Reactions to Fluorescein and Indocyanine Green in Retinal Angiography: Review of Literature and Proposal for Patient’s Evaluation |
title_sort |
immediate reactions to fluorescein and indocyanine green in retinal angiography: review of literature and proposal for patient’s evaluation |
publisher |
Dove Medical Press |
publishDate |
2020 |
url |
https://doaj.org/article/f99a84d0e0074e989c438ef5c2bb22a4 |
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